Glycerin 22 Men's Neutral Running Shoe - Maximum Cushioning

Our review of the Glycerin 22 Men's Neutral Running Shoe finds it best for runners and walkers who want plush cushioning without extra stability hardware. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells for softer landings and more energetic toe-offs. It comes across as a comfortable, everyday road running shoe that also works well for cross training and long walks, and it carries medical approvals that matter to users who need extra foot-friendly features.

Key Features

• Neutral support: Provides a high level of cushioning while maintaining a neutral platform ideal for runners who do not need corrective support.
• DNA Tuned cushion: Larger heel cells deliver plush landings while smaller forefoot cells create a responsive toe-off for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches to reduce pressure points while keeping the foot well ventilated during runs or daily wear.
• Smooth transitions: A broad platform plus tuned heel and forefoot stability helps the foot roll comfortably from heel to toe.
• Medical acceptance: Certified PDAC A5500 and granted the APMA Seal of Acceptance, offering reassurance for diabetic and foot-health conscious buyers.

Who It's For

The Glycerin 22 is aimed at men seeking the maximum amount of cushioning in a neutral shoe, including road runners, gym users and people who spend long hours on their feet. It is also a good choice for walkers and anyone who values plush heel padding combined with a responsive forefoot.

Runners who need strong corrective support or rigid motion control should look at stability-specific models such as the Glycerin GTS line. Those needing a very narrow fit or a radically minimalist shoe should consider other options, since fit impressions vary among buyers.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that reduces impact on long runs and walks.
• Breathable, durable double jacquard knit upper that adapts to the foot for comfort.
• Engineered midsole tuning that balances soft landings with lively toe-offs for smoother gait transitions.
• Recognized by PDAC and APMA for foot health, useful for diabetic or sensitive-foot users.

Cons

• Some customers report inconsistent fit, with opinions split between too narrow and ideal for wide feet, so trying before buying is recommended where possible.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Approvals	PDAC A5500 certified; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Glycerin 22 is a strong pick for men who prioritize plush cushioning and a smooth ride on pavement or during everyday use. Its tuned midsole and accommodating knit upper offer comfort and value, and the medical recognitions add credibility for those with foot-health concerns.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers consistently praise the cushioning and heel padding, making the shoe well suited for long walks and daily wear.

Do they run true to size?
Fit reports vary; some find them true to size while others find them narrow, so trying them on is advised if a precise fit is critical.

Is this shoe supportive for diabetic feet?
It is PDAC A5500 certified and has the APMA Seal of Acceptance, indicating it meets standards often recommended for diabetic and sensitive feet.