Glycerin GTS 22 Women's Supportive Running Shoe - Cushioned GuideRails

Our review of the Glycerin GTS 22 finds it best suited for women who want a plush, stable everyday running shoe that tames excess motion without sacrificing softness. The most compelling reason to buy is the combination of DNA Tuned cushioning with the GuideRails support system, which together deliver luxurious landings and controlled toe-offs, making runs and cross-training feel smoother. For runners who value comfort, breathable fit, and stability on road runs or gym sessions, this shoe balances protection and responsiveness in a package that updates the Glycerin GTS 21.

Key Features

• GuideRails support: Keeps excess motion at bay and helps stabilise the knee and foot during long runs or varied workouts.
• DNA Tuned cushion: Dual-size midsole cells provide soft, plush heel landings and a responsive forefoot for easier toe-offs.
• Accommodating fit: Double jacquard knit upper stretches and breathes to reduce pressure points while remaining durable.
• Smooth transitions: A broad platform with a tuned heel and forefoot promotes stable heel-to-toe roll.
• Diabetic-friendly option: Certified PDAC A5500 status indicates suitability for those needing extra depth and diabetic shoe considerations.

Who It's For

The Glycerin GTS 22 suits female road runners who prioritise cushioning and stability over a minimal or race-focused feel. It is a strong choice for daily training, long easy runs, walkers, and people who combine running with gym workouts, thanks to its supportive GuideRails and plush midsole.

Runners who prefer a very wide toe box or a firmer, more responsive racing shoe should look elsewhere; some users report a narrower feel in the toe area and the plush DNA Tuned foam leans toward comfort rather than maximum energy return for fast tempos.

Pros & Cons

Pros

• Exceptional comfort and cushioning for long runs and recovery days.
• Reliable support from GuideRails that helps limit excess motion.
• Breathable, flexible upper that provides an accommodating fit for many foot shapes.

Cons

• Some users find the toe box too narrow, so width-sensitive runners may need to try before buying.

Specifications

Our Verdict

The Glycerin GTS 22 is a top pick for women seeking cushioned, stable daily trainers that protect against excess motion while delivering plush landings. It represents good value for runners who prioritise comfort and support, though those needing a very roomy toe box or a race-oriented shoe should compare other models.

Frequently Asked Questions

Do these run true to size?
Fit varies by runner; some find the shoe true to size while others note a slightly narrow toe box, so consider trying them on if width is a concern.

Are these good for long runs?
Yes, the DNA Tuned cushioning and GuideRails support make them well suited to long, easy runs and recovery days.

Can I use them for gym and cross training?
Yes, their stable platform and accommodating upper work well for gym sessions and mixed workouts.