Brooks Glycerin 22 Neutral Running Shoe - Plush Cushioning and Smooth

In this review of the Brooks Glycerin 22 Neutral Running Shoe, the bottom line is simple: this is a plush, neutral road running shoe built for runners and walkers who prioritize cushioning and smooth transitions. The Glycerin 22 stands out for its new DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, and its certification as a PDAC A5500 Diabetic shoe plus the APMA Seal of Acceptance. Those seeking maximum cushioning in a neutral platform will find the ride notably soft without feeling overly unstable.

Key Features

• DNA Tuned Cushion: Dual-size cells in the midsole create a balance of plush heel cushioning and responsive forefoot toe-offs for smoother transitions.
• Neutral Support: Designed as a neutral shoe, it provides maximum cushioning without added corrective guidance, making it versatile for road running and gym use.
• Accommodating Fit: The double jacquard knit upper delivers flexible stretch and breathability while maintaining durability in high-wear areas.
• Smooth, Stable Platform: A broad base with a tuned heel and forefoot helps stabilize the foot and smooth heel-to-toe motion during long runs or walks.
• Health Certifications: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, indicating suitability for users needing diabetic-friendly footwear and overall foot health considerations.

Who It's For

The Glycerin 22 is best for recreational and distance road runners, walkers, and cross-training users who want maximum cushioning in a neutral shoe and appreciate a soft, protective ride. It is also a strong choice for people who need diabetic-friendly footwear or who value podiatric endorsement, thanks to the PDAC and APMA recognition.

Runners who require strong stability or motion control should consider alternatives such as the Glycerin GTS lineup for added support, and those who prefer a firmer, minimal-feel shoe might look elsewhere; this model emphasizes plush cushioning over a barefoot-like connection to the road.

Pros & Cons

Pros

• Exceptional cushioning and comfort for long walks and runs, praised by multiple users.
• Supportive platform that stabilizes foot movement and helps knee and hip comfort for some wearers.
• Breathable, flexible double jacquard knit upper that accommodates different foot shapes.
• Health-focused certifications make it appropriate for diabetic foot care and general foot wellness.

Cons

• Sizing feedback is mixed with some customers reporting the shoe runs small, so careful sizing or trying on first is advised.
• Price perception varies among buyers; some find the value excellent while others question the cost relative to alternatives.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned dual-size cells
Upper	Double jacquard knit for flexibility and breathability
Certifications	PDAC A5500 Diabetic shoe; APMA Seal of Acceptance
Best use	Road running, cross training, gym, walking

Our Verdict

The Brooks Glycerin 22 is a top pick for runners and walkers who want maximum cushioning in a neutral shoe and value a smooth, stable ride. Its DNA Tuned cushioning and accommodating knit upper deliver comfort and responsiveness, and the health certifications add confidence for users with foot care concerns. If you need motion control or a firmer feel, consider a different model; otherwise this shoe is a solid value for comfort-first runners.

Frequently Asked Questions

Do these run true to size?
Customers report mixed sizing; some find them small, so try on or size up if between sizes.

Are they good for long-distance running?
The plush midsole and stable platform make them suitable for long road runs and recovery miles.

Is this shoe suitable for diabetic foot care?
Yes, it is certified PDAC A5500 and has earned the APMA Seal of Acceptance, indicating suitability for diabetic-friendly footwear needs.