Brooks Glycerin 22 Neutral Running Shoe - Plush Cushioning for Road IS

In this review of the Brooks Glycerin 22 Neutral Running Shoe the bottom line is simple: runners who want maximum cushioning and smooth transitions will find a lot to like. The Glycerin 22 uses Brooks' latest DNA Tuned midsole to blend larger heel cells for soft landings with smaller forefoot cells that encourage energetic toe-offs, delivering a plush but responsive ride. It also carries the APMA Seal of Acceptance and is a certified PDAC A5500 diabetic shoe, which reinforces its focus on comfort and foot health rather than aggressive motion control.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide a soft, plush landing while smaller forefoot cells offer a more energetic toe-off for smoother strides.
• Neutral Support: Designed for neutral runners, the shoe gives maximum cushioning without added stability posts so it works well for road running and cross training.
• Accommodating Fit: The double jacquard knit upper stretches to fit wider feet comfortably while maintaining breathability and durability.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and promotes steady heel-to-toe movement.
• Foot Health Certifications: Certified PDAC A5500 for diabetic use and granted the APMA Seal of Acceptance, signaling thoughtful design for comfort and support.

Who It's For

The Glycerin 22 is aimed at neutral road runners and walkers who prioritize cushioning and a soft heel feel, especially those with wide feet or flat arches who appreciate extra volume and support around the heel. It suits daily miles, gym sessions, long walks, and runners seeking a plush trainer rather than a race shoe.

Shoppers who need firm motion control or a corrective support structure should look at stability-specific models such as the Glycerin GTS line. Also, performance-focused racers who want a lightweight, minimal-cushion race flat will find the Glycerin 22 heavier and more cushioned than ideal.

Pros & Cons

Pros

• Exceptional heel cushioning that customers consistently call comfortable for walking and running.
• Accommodating knit upper that works well for wider feet without feeling tight.
• Certified for diabetic use and awarded the APMA Seal, supporting foot health concerns.

Cons

• Some buyers report inconsistent sizing, so trying on or verifying return options is advisable.
• Higher price point noted by some customers, which may be a drawback if value is the top priority.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Glycerin 22 is an excellent choice for runners and walkers who want plush cushioning, a roomy fit, and smooth heel-to-toe transitions; its certifications also make it a thoughtful option for foot health. While the price and occasional sizing variability are worth noting, the combination of comfort, breathable upper, and tuned midsole makes it a strong value for anyone prioritizing daily comfort over racing performance.

Frequently Asked Questions

Do these run wide?
The double jacquard knit upper is accommodating and many customers with wider feet report a comfortable fit, though sizing experiences vary.

Is this shoe good for flat feet?
The neutral design offers cushioning and a broad platform that provides support for many runners with flat feet, but those needing firm corrective support should consider a stability model.

Can I use these for walking and gym workouts?
Yes; customers praise the cushioning and support for walking, road running, and cross training in the gym.