Brooks Glycerin 22 Neutral Running Shoe - Plush Cushioning Shoes

Our review of the Brooks Glycerin 22 finds it best suited for runners and walkers who prioritize maximum cushioning and a smooth ride. The standout reason to buy is the updated DNA Tuned cushion, which blends larger heel cells for soft landings with smaller forefoot cells for livelier toe-offs, delivering noticeably plush yet responsive transitions on road surfaces. This model is also certified as a PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, making it a compelling option for anyone seeking comfort with verified foot health credentials.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide soft, plush landings while smaller forefoot cells promote responsive toe-offs for smoother gait transitions.
• Neutral Support: Designed for neutral runners who want the maximum amount of cushioning without added stability features, suitable for road running and gym use.
• Accommodating Fit: A double jacquard knit upper offers flexibility and breathability while adapting to varied foot shapes for comfort over long distances.
• Stability from Platform: A broad midsole platform stabilizes the foot and works with the tuned heel and forefoot to smooth heel-to-toe movement.
• Certified Foot Health: PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance indicate suitability for foot health concerns and added confidence for sensitive feet.

Who It's For

The Glycerin 22 is ideal for recreational and daily runners who prioritize maximum cushioning and a forgiving ride, including walkers and gym users who want a soft, protective sole. It works well for road training, long easy runs, and anyone who appreciates a roomy toe box and plush underfoot feel.

Runners seeking firm responsiveness, minimal weight, or built-in motion control should look elsewhere; those needing extra medial support should consider the Glycerin GTS 22 or other guidance-featured models rather than this neutral shoe.

Pros & Cons

Pros

• Exceptional cushioning that makes long walks and runs feel less jarring on knees and hips.
• Comfortable and breathable double jacquard knit upper that accommodates varied foot shapes.
• Certified as a PDAC A5500 diabetic shoe with APMA acceptance, helpful for users with foot health concerns.
• Smooth, stable transitions helped by the broad platform and tuned midsole geometry.

Cons

• Sizing opinions vary; some wearers report the fit runs small, so trying on or sizing up may be necessary.
• Maximum cushioning adds bulk and weight compared with minimalist or racing shoes.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size cell cushioning
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Glycerin 22 is a strong choice for runners and walkers who want plush, protected cushioning and smooth transitions, backed by diabetic and APMA certifications. It delivers value for those who prioritize comfort and foot health, though those after a lighter, firmer ride or added support should explore alternate models.

Frequently Asked Questions

Are these shoes good for long-distance walking?
Yes, the maximum cushioning and broad platform make the Glycerin 22 well suited for long walks and extended wear without sharp impact.

Do they provide support for overpronation?
No, the Glycerin 22 is a neutral shoe; runners needing extra medial support should consider the Glycerin GTS 22 or stability-specific models.

How does sizing run?
Customers report mixed experiences; some find them extremely small, so trying them on or ordering a half size up is advised if between sizes.