Brooks Glycerin 22 Neutral Running Shoe - Soft Cushioned Support

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a cushioned, supportive trainer for women who prioritize long-distance comfort and joint support. The shoe stands out for its plush DNA Tuned Nitro-Infused foam midsole that delivers a soft, squishy ride, and an engineered double jacquard mesh upper that breathes while holding the foot securely. Reviewers repeatedly mention excellent cushioning and support for knees and hips, making it a sensible choice for walkers, daily trainers, and runners seeking a forgiving feel.

Key Features

• DNA Tuned Nitro-Infused foam: provides a soft, responsive cushioning that helps reduce impact on knees and hips during long walks or runs.
• Engineered double jacquard mesh upper: offers breathable coverage with structured support that keeps the foot secure without feeling tight.
• Roomy toe box: accommodates natural toe splay for comfort on long miles and for those who prefer more space up front.
• Supportive midsole geometry: helps stabilize the foot through the gait cycle and contributes to a smoother, more confident stride.
• Plush sole feel: a soft, squishy sensation underfoot that many customers describe as comfortable for extended walking and standing.

Who It's For

The Glycerin 22 suits runners and walkers who want maximum cushioning and joint-friendly support, especially those who log longer distances or spend hours on their feet. It is a good choice for anyone who values a plush ride and a roomy toe box for comfort rather than a race-flat feel.

Runners who need a very snug, performance-oriented fit or who prefer a minimal, firm midsole might look elsewhere; also, shoppers who are unsure about sizing should try these on or check sizing notes closely, as customers report mixed sizing experiences.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that many users report relieves knee and hip discomfort on long walks.
• Supportive construction that stabilizes the foot while maintaining a soft ride.
• Breathable engineered mesh upper that balances airflow with structure.
• Roomy toe box that improves comfort for longer wear and natural toe movement.

Cons

• Sizing can be inconsistent for some wearers, with reports that they run smaller than expected, so fit checks are recommended.
• Firmer performance runners may find the plush feel less energetic for speed work.

Specifications

Brand	Brooks
Model	Glycerin 22
Intended use	Neutral running / daily training
Midsole foam	DNA Tuned Nitro-Infused foam
Upper	Engineered double jacquard mesh
Fit notes	Roomy toe box; customers report mixed sizing

Our Verdict

The Brooks Glycerin 22 is a strong choice for runners and active walkers who want plush cushioning and joint-friendly support without sacrificing breathable upper construction. It represents good value if comfort and long-distance wearability are priorities, though buyers should verify sizing before committing.

Frequently Asked Questions

Do these shoes provide good support for knee pain?
Many customers report improved comfort and reduced knee and hip strain thanks to the plush DNA Tuned Nitro-Infused foam and supportive midsole geometry.

Should I size up or down?
Customers disagree on sizing and some say they run small; try them on if possible or consult retailer sizing guidance before ordering.

Are they suitable for speedwork?
The Glycerin 22 favors cushioning and comfort over a firm, responsive ride, so it is better for daily training and long runs than dedicated speed sessions.