Brooks Glycerin GTS 22 Neutral Running Shoe - Cushioned Support

In this review of the Brooks Glycerin GTS 22, the bottom line is straightforward: this is a plush, supportive road-running shoe best suited to runners and walkers who want maximum cushioning with guidance to limit excess motion. The Glycerin GTS 22 blends Brooks DNA Tuned midsole technology with the GuideRails support system to deliver soft landings and energetic toe-offs while stabilizing the foot. It is also one of the few daily trainers certified as a PDAC A5500 diabetic shoe, making it a strong option for anyone needing dependable cushioning and foot protection.

Key Features

• DNA Tuned Cushion: Larger heel cells offer soft, plush landings while smaller forefoot cells promote responsive toe-offs for balanced ride quality.
• GuideRails Support: The holistic GuideRails system keeps excess motion in check to protect knees and hips during long runs or all-day wear.
• Accommodating Fit: The double jacquard knit upper stretches for a breathable, comfortable wrap that adapts to foot shape while remaining durable.
• Smooth, Stable Transitions: A broad platform and tuned heel-to-toe geometry create stable, seamless transitions from landing through push-off.
• Certified Diabetic Option: PDAC A5500 certification means it meets standards for diabetic footwear, adding a layer of suitability for sensitive feet.

Who It's For

The Glycerin GTS 22 is ideal for road runners, gym-goers, and daily walkers who prioritize cushioning and supportive control over a race-day lightweight feel. Runners with mild pronation or those who appreciate extra stability without rigid orthotics will find the GuideRails system helpful.

Those seeking a narrow race shoe, a minimalist ride, or the highest possible durability for heavy daily mileage on abrasive surfaces might want to look elsewhere, since some customers report mixed fit impressions and concerns about long-term durability.

Pros & Cons

Pros

• Exceptional comfort and cushioning for long runs or all-day wear.
• Support that stabilizes excess motion with the GuideRails system.
• Breathable, flexible upper that provides an accommodating fit.
• PDAC A5500 certification makes it suitable for diabetic foot care needs.

Cons

• Fit can be inconsistent for some users, with a few finding the shoe narrower than expected.
• Some customers report concerns about long-term durability under heavy use.

Specifications

Model	Glycerin GTS 22
Support System	GuideRails holistic support
Midsole Technology	DNA Tuned cushioning with variable cell sizes
Upper	Double jacquard knit, breathable and accommodating
Best Use	Road running, cross training, gym, all-day wear
Diabetic Certification	PDAC A5500 certified
Predecessor	Glycerin GTS 21

Our Verdict

The Brooks Glycerin GTS 22 is a strong choice for runners and walkers who want plush cushioning combined with stabilizing support. It delivers smooth transitions and reliable comfort, and its diabetic certification adds practical value. If you need a responsive yet soft daily trainer that protects against excess motion, this shoe is worth considering; those after a narrow racing profile or extreme longevity under heavy mileage should evaluate fit and durability first.

Frequently Asked Questions

Are these shoes good for overpronation?
The GuideRails support system helps control excess motion, making the Glycerin GTS 22 a good option for mild to moderate overpronation.

Do they run true to size?
Fit is mixed: many users find them true to size and accommodating, but some report a narrower feel-try your usual size and consider half sizes if you are between.

Can these be used for everyday walking?
Yes, the plush DNA Tuned cushioning and stable platform make them comfortable for daily walking and all-day wear.