Brooks Glycerin GTS 22 Supportive Running Shoe - Smooth, Cushioned

Our review of the Brooks Glycerin GTS 22 finds it best for runners and active women who prioritize plush cushioning and gentle stability. The single biggest reason to buy is the combination of the new DNA Tuned midsole and the GuideRails support system, which together provide notably soft landings and controlled motion for smoother heel-to-toe transitions. It is also a certified PDAC A5500 diabetic shoe, making it a strong option for walkers and those needing extra foot protection without giving up a responsive feel.

Key Features

• DNA Tuned Cushion: Larger heel cells deliver soft, plush landings while smaller forefoot cells give a responsive toe-off for balanced rides.
• GuideRails Support: Holistic support keeps excess motion in check to stabilize the foot and reduce strain on knees during long runs or everyday wear.
• Accommodating Fit: The double jacquard knit upper adapts to the foot for breathability and flexible comfort without feeling restrictive.
• Smooth Transitions: A broad platform with a tuned heel and forefoot smooths heel-to-toe movement for stable strides on road surfaces.
• Certified Diabetic Option: The shoe meets PDAC A5500 guidelines, offering extra reassurance for diabetics who need protective footwear.

Who It's For

The Glycerin GTS 22 is ideal for women who run on roads, use the gym, or walk frequently and want a plush, supportive shoe that reduces excess motion. Runners with mild overpronation or anyone who prefers extra medial support will appreciate the GuideRails system paired with soft DNA Tuned foam.

It may not be the top choice for those seeking an ultra-lightweight racer or a minimalist trainer, since the focus here is on cushioning and stability rather than minimal mass or maximum responsiveness for speedwork.

Pros & Cons

Pros

• Exceptional cushioning that customers describe as life-changing for long runs and recovery days.
• GuideRails provide tangible support and stabilizing feel without feeling bulky.
• Comfortable, breathable knit upper that fits an accommodating range of foot shapes.
• Certified PDAC A5500 diabetic shoe for added protection and peace of mind.

Cons

• Some users report the toe box can feel narrow, so those needing a wide forefoot should try sizing or a different model.
• Heavier than lightweight racing shoes, so not ideal for fast tempo runs.

Specifications

Model	Glycerin GTS 22
Support System	GuideRails holistic support
Midsole Technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit
Use Case	Road running, gym, cross training, everyday walking
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Glycerin GTS 22 is a strong choice for women who want plush cushioning with reliable support; its DNA Tuned midsole and GuideRails system deliver comfortable, stable runs and walks. It represents good value for anyone who prioritizes comfort, joint protection, and a forgiving ride over lightweight speed.

Frequently Asked Questions

Are these shoes good for beginners?
Yes, beginners who want cushioning and stability will find the Glycerin GTS 22 forgiving and protective for regular road miles.

Do they run true to size?
Customer reports vary; some find the fit true while others note a narrower toe box, so trying on or checking return options is recommended.

Can diabetics use these shoes?
Yes, the Glycerin GTS 22 is PDAC A5500 certified, making it suitable for many diabetics who need protective footwear.