Brooks Glycerin GTS 22 Supportive Running Shoe - Smooth Cushioning

Our review of the Brooks Glycerin GTS 22 finds it best for runners and active women who want plush cushioning with added stability. The standout reason to consider these shoes is the combination of DNA Tuned cushion and GuideRails support, which together deliver soft landings and controlled transitions that reduce excess motion. For those seeking a comfortable daily trainer that handles road runs, gym sessions and long walks, the Glycerin GTS 22 balances luxury underfoot with structural support without feeling overly rigid.

Key Features

• DNA Tuned Cushion: Dual-size midsole cells create a soft heel landing and a responsive forefoot for energetic toe-offs during runs.
• GuideRails Support: Holistic support system keeps excess motion in check so the foot and knee stay aligned over longer workouts.
• Accommodating Fit: Double jacquard knit upper stretches where needed and breathes well to reduce hot spots on longer miles.
• Smooth Transitions: A broad platform with a tuned heel and forefoot promotes stable, seamless heel-to-toe movement.
• Certified Diabetic Option: The shoe is a PDAC A5500 certified diabetic shoe, making it appropriate for runners who require that medical classification.

Who It's For

The Glycerin GTS 22 is ideal for women who prioritize cushioning and support over minimal, race-oriented shoes: road runners logging medium to high weekly mileage, gym-goers who want stability for cross training, and anyone who values a plush ride with guidance to limit excessive pronation. The shoe's certification also makes it a thoughtful option for shoppers needing diabetic-friendly footwear.

Runners who want a very wide toe box or a firmer, faster racing shoe should look elsewhere; some users report the toe box feels narrower than expected, so those with wide forefeet may prefer a purpose-built wide model or different family line.

Pros & Cons

Pros

• Exceptional underfoot comfort from the tuned midsole that balances plush landings and responsive toe-offs.
• Reliable stabilization thanks to GuideRails, which helps reduce excess motion without feeling restrictive.
• Breathable, flexible double jacquard knit upper that conforms to the foot for a secure fit.

Cons

• Some wearers find the toe box narrow, so sizing and fit can be inconsistent for wider feet.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support	GuideRails holistic support
Cushion Technology	DNA Tuned dual-size midsole cells
Upper	Double jacquard knit, breathable
Recommended Use	Road running, cross training, gym
Medical Classification	PDAC A5500 diabetic shoe certified

Our Verdict

The Brooks Glycerin GTS 22 is a strong choice for women who want plush cushioning plus structured support for everyday training. It delivers a cushy, controlled ride and durable build that justify the investment for runners who value comfort and stability; just verify fit if you have a wider toe box.

Frequently Asked Questions

Are these shoes good for long road runs?
Yes. The DNA Tuned midsole and broad platform provide cushioned landings and stable transitions suited to longer road sessions.

Do they offer strong stability features?
Yes. The GuideRails system limits excess motion and supports natural movement paths without feeling overly restrictive.

Should I size up for a wider toe box?
Some customers report a narrow toe box, so trying a half size up or testing a wide version if available is recommended for wider feet.