Brooks Glycerin GTS 22 Supportive Running Shoe - Smooth (Style 45YS)

In this review of the Brooks Glycerin GTS 22 Supportive Running Shoe the bottom line is simple: these are cushioned, supportive road shoes built for runners and active men who need stable, comfortable long miles or all-day wear. The single biggest reason to buy is the combination of GuideRails support with the new DNA Tuned midsole, which delivers plush landings in the heel and responsive toe-offs for smoother transitions. Reviewers consistently praise comfort and pain relief while noting the fit can be snug in the toe for some feet.

Key Features

• GuideRails support: Keeps excess motion in check to stabilize the foot and reduce strain during runs or extended standing.
• DNA Tuned cushion: Larger heel cells provide soft landings while smaller forefoot cells offer energetic toe-offs for balanced propulsion.
• Accommodating fit: The double jacquard knit upper adapts to foot shape while offering breathability and durability for varied workouts.
• Broad platform: A wider base improves steadiness and creates smoother heel-to-toe transitions on roads and treadmills.
• Certified diabetic option: The shoe is PDAC A5500 certified, making it suitable for men who need approved diabetic footwear.

Who It's For

The Glycerin GTS 22 is best for road runners, gym-goers and men who value cushioning with corrective support - especially those who have experienced foot pain and need arch stability. It works well for long training runs, daily miles and mixed gym sessions where a smooth, protected ride matters.

Runners seeking a very wide toe box or a minimalist, low-profile shoe should look elsewhere; a minority of customers report the toe area runs a bit narrow. If you prefer a neutral, non-supported ride, the non-GTS Glycerin 22 is the alternative to consider.

Pros & Cons

Pros

• Excellent cushioning that relieves foot pain for users who need more shock absorption.
• Reliable support from the GuideRails system to limit excess motion and stabilize runs.
• High-quality build and breathable upper that combine comfort with durability for daily wear.

Cons

• Some wearers find the fit too narrow in the toe area, so those needing roomy toe space should try before buying.

Specifications

Model	Glycerin GTS 22
Support System	GuideRails holistic support
Midsole Technology	DNA Tuned dual-size cell cushion
Upper	Double jacquard knit for flexible, breathable fit
Platform	Broad platform for stable transitions
Certification	PDAC A5500 diabetic shoe certified

Our Verdict

The Brooks Glycerin GTS 22 is a strong choice for men who need plush cushioning plus corrective support to reduce pain and stabilize gait. It represents fair value for runners and active users who prioritize comfort and long-run protection, though those needing extra toe volume should check fit before committing.

Frequently Asked Questions

Are these shoes good for long training runs?
Yes. The DNA Tuned cushioning and broad platform make them well suited for long road miles and longer training sessions.

Do they provide arch support for overpronation?
Yes. The GuideRails system is designed to keep excess motion in check and offers support that helps stabilize the arch and gait.

Do they fit wide feet comfortably?
Some customers report a snug toe area, so men with wide toes should try them on or consider sizing up for more room.