Brooks Glycerin GTS 22 Supportive Women's Running Shoe

In this review the Brooks Glycerin GTS 22 emerges as a cushioned, supportive road running shoe for women who need stability without sacrificing plush comfort. The biggest reason to buy is the combination of the latest DNA Tuned cushioning and the GuideRails support system, which together deliver smooth heel-to-toe transitions while keeping excess motion in check. It is also notable as a certified PDAC A5500 diabetic shoe, making it a strong choice for runners or walkers seeking both protection and a soft, responsive ride.

Key Features

• GuideRails support: Keeps the foot aligned and limits excess motion so the wearer experiences steadier strides and reduced strain on knees and hips.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot combine for plush landings and energetic toe-offs.
• Accommodating fit: The double jacquard knit upper stretches where needed while remaining durable and breathable for longer runs or gym sessions.
• Stable platform: A broad base and tuned heel smooth transitions from heel to toe for controlled, confident steps.
• Certified diabetic friendly: PDAC A5500 designation makes it suitable for users needing extra foot protection and medical shoe support.

Who It's For

The Glycerin GTS 22 is best for women who want maximum cushion plus structure, such as long-distance road runners, walkers with mild pronation, or anyone who benefits from support during cross training. Runners seeking a plush feel but who still require guidance on stride path will find the GuideRails helpful.

Those who prefer a narrow racing fit, ultra-minimal shoes, or a dramatically firmer ride should look elsewhere; the GTS 22 prioritizes stability and softness over a stripped-down or highly responsive racing platform.

Pros & Cons

Pros

• Exceptional cushioning that absorbs impact and eases foot pain for many users.
• GuideRails system provides reliable support and helps reduce excess movement.
• Breathable, flexible double jacquard knit upper offers an accommodating fit for varied foot shapes.
• Certified PDAC A5500 diabetic shoe adds medical suitability for those who need it.

Cons

• Fit can be mixed: some users report a roomy toe box while others find it narrow, so sizing may require trying on first.
• Cushioning preference varies; runners who want a firmer, more responsive feel may find it too plush.

Specifications

Model	Glycerin GTS 22
Support System	GuideRails holistic support
Cushioning	DNA Tuned midsole with variable cell sizes
Upper	Double jacquard knit, breathable and accommodating
Primary Use	Road running, cross training, gym
Medical Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Glycerin GTS 22 is a strong choice for women who need plush cushioning combined with dependable support; its DNA Tuned midsole and GuideRails system deliver comfort and stabilized motion that can reduce foot, hip, and back discomfort. It offers good value for long runs, daily training, or anyone seeking a supportive, medical-friendly running shoe, though shoppers should verify fit for their toe shape before committing.

Frequently Asked Questions

Are these shoes good for overpronation?
The GuideRails support system helps manage excess motion and is well suited for mild to moderate overpronation.

Do they run true to size?
Fit reports are mixed; some wearers find the toe box roomy while others find it narrow, so trying the shoe on or checking retailer return policies is recommended.

Is this shoe suitable for diabetic feet?
Yes, the Glycerin GTS 22 is certified PDAC A5500, indicating it meets standards for diabetic shoe use and extra foot protection.