Brooks Mens Glycerin 22 Neutral Running Shoe - Cushioned Road Trainer

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is straightforward: this is a plush, neutral road trainer built for runners and walkers who prioritize cushioning and smooth transitions. The Glycerin 22 uses Brooks DNA Tuned midsole cells to give softer landings in the heel and a more responsive forefoot push-off, and it carries both APMA acceptance and PDAC A5500 diabetic certification, which makes it a strong candidate for anyone seeking roomy comfort and protective features during everyday runs or long walks.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot create soft landings and energetic toe-offs for a balanced ride.
• Neutral Support: Designed as a neutral shoe, it offers maximum cushioning without added stability posts, suitable for those who do not need corrective support.
• Accommodating Fit: The double jacquard knit upper provides flexible stretch and breathability while holding the foot securely for daily wear.
• Smooth Transitions: A broad platform with a tuned heel and forefoot smooths heel-to-toe roll for reduced harshness during each stride.
• Medical Certifications: Certified PDAC A5500 for diabetic need and granted the APMA Seal of Acceptance, indicating suitability for foot health concerns.

Who It's For

The Glycerin 22 is best for neutral runners, walkers, and gym-goers who want the maximum level of cushioning in a road-friendly shoe. Its plush midsole and accommodating upper make it well suited to longer daily walks, treadmill running, and anyone who values a soft heel strike and energetic forefoot without added motion control.

Runners who require strong corrective support should look elsewhere or consider the Glycerin GTS variant that adds guidance features. Those who need an extremely narrow race-day racer or a minimalist shoe will also find the Glycerin 22 heavier and more cushioned than those specialized options.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact and feels comfortable for long walks and runs.
• DNA Tuned midsole gives a blend of soft landings and responsive toe-offs for smoother transitions.
• Accommodating knit upper offers breathable comfort and a secure fit for daily use.
• Recognized by APMA and certified PDAC A5500, making it suitable for foot health considerations.

Cons

• Fit feedback is mixed: some users find it narrow while others report it fits wide feet, so sizing may vary by foot shape.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit for breathability and flexibility
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a strong pick for runners and walkers who want maximum cushioning, smooth heel-to-toe transitions, and a comfortable, breathable upper. Its medical certifications add confidence for foot health needs, though potential buyers should confirm fit-some find it narrow. Overall it delivers excellent cushioning and durability, making it good value for everyday training and long walks.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. The plush DNA Tuned cushioning and broad platform make the Glycerin 22 comfortable for extended walking and daily wear.

Do they provide stability for overpronation?
No. This is a neutral shoe; runners needing added support should consider the Glycerin GTS or a stability model.

Do they run true to size?
Reports vary: some users find the fit true or roomy, while others experience a narrower fit, so try your usual size or check return options.