Brooks Mens Glycerin 22 Neutral Running Shoe for Men - Smooth

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe, the bottom line is simple: this shoe is for runners and walkers who want maximum plush cushioning with smooth heel-to-toe transitions. The standout reason to consider the Glycerin 22 is its DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs without sacrificing a neutral ride. As a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, it also appeals to anyone seeking medically minded comfort and reliable everyday support.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot create plush, stable landings and responsive toe-offs for smoother runs.
• Neutral Support: Designed as a neutral shoe, it provides maximal cushioning without corrective support, making it versatile for road running and the gym.
• Accommodating Fit: A new double jacquard knit upper delivers flexibility and breathability while fitting a range of foot shapes comfortably.
• Smooth Transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and promotes steady heel-to-toe motion.
• Medical Acceptance: Certified PDAC A5500 and bearing the APMA Seal of Acceptance, it supports foot health and everyday comfort for sensitive needs.

Who It's For

The Glycerin 22 is best for men who prioritize plush cushioning and comfort over corrective stability, including road runners, cross trainers, and people who spend a lot of time walking or on their feet. Its neutral platform and DNA Tuned midsole suit those who want a soft ride that still feels lively at toe-off.

Those who need strong motion control or heavy overpronation support should look elsewhere, such as guide-rail or stability-focused models. Also, buyers seeking a narrow, race-oriented racer with minimal cushioning will find this shoe too cushioned and substantial for fast tempo running.

Pros & Cons

Pros

• Exceptional cushioning and comfort for long walks and recovery runs.
• DNA Tuned midsole balances plush landings with responsive toe-offs.
• Accommodating knit upper offers breathable, flexible fit for daily wear.
• Certified PDAC A5500 and APMA accepted for foot health considerations.

Cons

• Fit can be inconsistent for some buyers, with mixed reports on narrowness versus room for wide feet.
• Not intended for runners seeking strong stability or a minimalist feel.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Medical Certifications	PDAC A5500 certified; APMA Seal of Acceptance
Ideal Uses	Road running, cross training, walking, everyday wear

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for men who want maximum cushioning without sacrificing smooth transitions or everyday comfort. Its DNA Tuned midsole and accommodating knit upper make it good value for runners and walkers who favor plush, supportive rides and those with foot health concerns that benefit from certified design.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers consistently note excellent cushioning and support that make the Glycerin 22 comfortable for extended walking and everyday wear.

Do they run true to size?
Fit reports are mixed; some users find them true to size or roomy for wider feet, while others feel they run a bit narrow, so try a fitting if possible.

Do these offer support for pronation?
No. The Glycerin 22 is a neutral shoe designed for cushioning and smooth transitions rather than corrective pronation control.