Brooks Mens Glycerin 22 Neutral Running Shoe - Plush

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a daily trainer for runners and walkers who want maximal, refined cushioning with smooth transitions. The Glycerin 22 builds on its predecessor with Brooks DNA Tuned midsole cells that combine plush landings and responsive toe-offs, and it carries both APMA acceptance and PDAC A5500 diabetic shoe certification, which underlines its comfort-focused design. Overall it is best for road runners, gym users and anyone who prioritizes cushioning and comfort over rigid support.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel create soft landings while smaller forefoot cells offer a responsive toe-off for balanced energy return.
• Neutral Support: Designed for neutral runners, the shoe provides the maximum amount of cushioning without added corrective support, keeping strides smooth on roads and treadmills.
• Accommodating Fit: The double jacquard knit upper stretches to adapt to the foot, combining breathability with a comfortable, secure hold across longer runs and walks.
• Smooth Transitions: A broad platform and tuned heel-to-toe geometry stabilize the foot and promote steady heel-to-toe movement for a less jarring ride.
• Medical Certifications: APMA Seal of Acceptance and PDAC A5500 diabetic shoe certification indicate attention to cushioning, support, and foot health for sensitive users.

Who It's For

The Glycerin 22 is ideal for neutral road runners who place a premium on cushioning and comfort during long runs or everyday walking, plus gym-goers who want a soft, stable platform for cross training. Its certifications also make it a sensible pick for buyers seeking extra foot protection and comfortable padding around the heel.

Runners who need pronounced stability or motion control should look at supportive alternatives, such as models with guiding rails or explicit support technology. Those who prefer an ultra-light racing shoe or a minimalist feel will likely find the Glycerin 22 heavier and too cushioned for speedwork.

Pros & Cons

Pros

• Exceptional cushioning and heel padding deliver comfortable, pain-free runs and long walks.
• Accommodating knit upper offers breathable fit and everyday comfort for many foot shapes.
• Smooth, stable transitions from heel to toe help reduce impact harshness on road surfaces.

Cons

• Fit reports are mixed; some users find the shoe narrow while others like it for wider feet, so sizing may require trying on.

Specifications

Our Verdict

The Brooks Glycerin 22 is a strong choice for runners and walkers who want maximum, refined cushioning and a smooth, stable ride. With its DNA Tuned midsole, accommodating knit upper, and medical certifications, it delivers notable comfort and value for daily training and long walks, though shoppers should check fit before buying if they are between widths.

Frequently Asked Questions

Are these shoes good for long-distance road runs?
Yes. The plush cushioning and smooth transitions suit long runs on pavement and reduce impact fatigue.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing motion control should choose a support-specific model.

How do they fit compared with previous versions?
The double jacquard knit upper changes the fit; some users report a roomier feel while others find them narrow, so trying them on is recommended.