Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioned

In this review the Brooks Mens Glycerin 22 stands out as a neutral daily trainer built for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for energetic toe-offs, delivering a noticeably cushioned yet responsive feel on road runs and long walks. It also arrives with clinical credentials as a certified PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, which reinforces its appeal for comfort and foot health.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot provide a balance of plush landings and lively toe-offs for road running and walking.
• Neutral Support: Designed as a neutral shoe that delivers maximal cushioning without imposing stability corrections, suitable for runners who do not overpronate.
• Accommodating Fit: The double jacquard knit upper offers flexibility and breathability while accommodating slightly wider feet comfortably.
• Smooth Transitions: A broad platform and tuned heel-to-forefoot geometry stabilize the foot and smooth heel-to-toe movement during long miles.
• Clinical Acceptance: Certified as a PDAC A5500 diabetic shoe and granted the APMA Seal of Acceptance, supporting users who need medically minded footwear.

Who It's For

The Glycerin 22 suits neutral runners and walkers who want maximum cushioning for daily road miles, recovery runs, or long walks; it is also a sensible pick for people seeking footwear cleared for diabetic use or recommended by foot care professionals. Runners who appreciate a plush heel feel but still want a responsive forefoot will find the midsole technology particularly effective.

Those who need motion-control or heavy stability features should look elsewhere, for example at support-focused models in the same family. Also, competitive racers seeking minimal weight and a fast, low-profile ride may prefer lighter, more performance-oriented shoes over this cushioned trainer.

Pros & Cons

Pros

• Exceptional heel cushioning that makes long walks and runs feel less jarring.
• Accommodating knit upper that provides breathable comfort for wider feet.
• PDAC and APMA acceptance adds confidence for users with foot health concerns.
• Stable, broad platform that helps create smooth heel-to-toe transitions.

Cons

• May be heavier and less suited to fast tempo runs or racers who prefer a minimal shoe.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Tech	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Clinical Approval	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who want maximum cushioning, a comfortable accommodating fit, and clinically minded features. It is good value for anyone prioritizing comfort and foot health during daily miles, but not the ideal pick for lightweight race-day speed or those needing heavy stability corrections.

Frequently Asked Questions

Are these shoes suitable for wide feet?
Yes, the double jacquard knit upper is flexible and accommodating, and many users report a comfortable fit for wider feet.

Can I use the Glycerin 22 for long walks?
Absolutely; the plush heel cushioning and stable platform make it well suited for long walks and recovery miles.

Is this shoe good for someone who overpronates?
It is a neutral shoe, so runners who need motion control or added support should consider a stability model instead.