Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioned Ride

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: these are road-running trainers built for maximum cushioning and smooth transitions. The Glycerin 22 uses Brooks' DNA Tuned midsole to marry a plush heel landing with a more responsive forefoot, and it is notable for being a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance. For runners or walkers who prioritize soft, protective cushioning and a stable platform, the Glycerin 22 delivers a comfortable, everyday shoe with reliable build quality.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells help deliver energized toe-offs.
• Neutral Support: Designed for neutral runners and walkers, it offers the maximum amount of cushioning without added corrective support.
• Accommodating Fit: The double jacquard knit upper gives a flexible, breathable fit that adapts to the foot for long hours of wear.
• Smooth, Stable Transitions: A broad platform combined with a tuned heel and forefoot promotes stable heel-to-toe motion on road surfaces.
• Medical Approvals: Certified as a PDAC A5500 Diabetic shoe and awarded the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 is best for neutral road runners, frequent walkers, and gym-goers who want maximal cushioning and a plush underfoot feel. Its certifications also make it a solid choice for people seeking a shoe approved for diabetic foot care or who need protective, comfortable daily footwear.

Runners who need firm motion control, a narrow racing fit, or very lightweight minimal shoes should look elsewhere, and those requiring pronounced stability features should consider the Glycerin GTS line for added support.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that reduce impact and feel comfortable on long walks or runs.
• Stable, broad platform and tuned midsole create smooth transitions from heel to toe.
• Durable, breathable double jacquard knit upper that accommodates movement and provides good breathability.
• Medical certifications (PDAC A5500 and APMA) add confidence for foot health and everyday use.

Cons

• Fit can be inconsistent between wearers; some report it narrower than expected while others find it roomy for wide feet.
• Maximum cushioning increases weight compared with minimalist or race-focused trainers.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a compelling choice for runners and walkers who want plush cushioning, stable transitions, and medical-minded comfort. It is good value for anyone prioritizing protection and everyday comfort, though those needing a narrow race fit or aggressive speed shoe should look elsewhere.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers commonly note the cushioning and heel padding make the Glycerin 22 excellent for walking and everyday wear.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral-support shoe; runners needing added stability should consider the Glycerin GTS variant.

How does the fit run?
Fit varies by person; some find the shoe perfect for wider feet while others report a narrower fit, so trying them on or ordering with an easy return is advised.