Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioned Ride 21

In this review the Brooks Mens Glycerin 22 is presented as a neutral running shoe built for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole that blends dual-size cells for soft landings and energetic toe-offs, delivering a comfortable ride for road runs, gym sessions, and long walks. It also carries the APMA Seal of Acceptance and PDAC A5500 diabetic certification, which reinforces its focus on comfort and foot health.

Key Features

• Neutral support: Designed to provide maximum cushioning without directional stability features, making it suited to neutral runners and daily wear.
• DNA Tuned cushion: Larger heel cells and smaller forefoot cells combine to give plush heel landings and responsive toe-offs for smoother gait cycles.
• Accommodating fit: The double jacquard knit upper offers flexibility and breathability while adapting to foot shape for long-wear comfort.
• Smooth, stable transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and guide heel-to-toe motion.
• Health-focused certifications: APMA Seal of Acceptance and PDAC A5500 diabetic shoe rating indicate suitability for users who need reliable cushioning and pressure relief.

Who It's For

The Glycerin 22 is best for neutral runners, walkers, and gym-goers who want maximum cushioning and a soft, forgiving ride. It works well for road running and everyday use when comfort and impact protection are priorities rather than corrective support.

Runners who need built-in stability or heavy pronation control should consider a support model instead, such as the Glycerin GTS line. Also, if you need a very narrow race-oriented shoe or minimal barefoot feel, this plush, cushioned trainer is not the ideal choice.

Pros & Cons

Pros

• Exceptional cushioning from the DNA Tuned midsole creates a plush, comfortable ride for long sessions.
• Accommodating double jacquard knit upper balances breathability with a stable hold for everyday use.
• Certified by APMA and PDAC A5500, supporting users who require diabetic-friendly footwear and proven foot protection.
• Broad platform and tuned geometry deliver smooth, stable transitions from heel to toe.

Cons

• Fit reports vary; some users find the shoe too narrow while others report it suits wide feet, so trying on for personal fit is recommended.
• Not intended for runners who need motion-control or heavy stability features.

Specifications

Brand	Brooks
Model	Glycerin 22
Support	Neutral
Midsole tech	DNA Tuned dual-size cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, smooth transitions, and foot-health certifications. It represents good value for those prioritizing comfort and impact protection, though shoppers should confirm fit due to mixed reports on width and sizing.

Frequently Asked Questions

Are these shoes suitable for diabetic feet?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal, indicating suitability for users needing extra cushioning and pressure relief.

Do they provide stability for overpronation?
No, this is a neutral support shoe; those needing motion control should consider a stability or GTS (guided support) model.

How do they fit compared with previous versions?
Fit varies by user: some report a comfortable, slightly roomy fit while others find them narrow, so trying them on or checking retailer fit guidance is advised.