Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioned Ride IS

In this review the Brooks Mens Glycerin 22 is presented as a top choice for runners and walkers who prioritize maximum cushioning and smooth transitions. The shoe's standout feature is the updated midsole with DNA Tuned, which blends larger heel cells and smaller forefoot cells to deliver plush landings and responsive toe-offs; that balance is the single biggest reason to consider these as daily trainers or walking shoes. The Glycerin 22 is also notable for being a certified PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, which underscores its accommodation and support for sensitive feet.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller forefoot cells work together to give soft landings without sacrificing energetic toe-offs.
• Neutral Support: Designed as a neutral shoe that provides the maximum amount of cushioning, suitable for road running and cross training.
• Accommodating Fit: The double jacquard knit upper flexes for a roomy, breathable fit that adapts well to wider feet and long walks.
• Smooth Transitions: A broad platform with a tuned heel and forefoot stabilizes the foot for predictable heel-to-toe movement.
• Medical Acceptance: Certified PDAC A5500 and APMA accepted, making it appropriate for users needing diabetic-friendly and podiatrist-approved footwear.

Who It's For

The Glycerin 22 suits runners and walkers who want a highly cushioned, neutral trainer for road miles, gym work, and everyday wear; it is especially appealing to those with wider feet or who need extra heel cushioning. Users who value medical endorsements will appreciate the PDAC A5500 certification and APMA Seal of Acceptance.

It is less appropriate for runners seeking a minimalist, low-drop shoe or those who require strong corrective support - customers needing additional stability should consider a GTS/stability variant instead of this neutral model.

Pros & Cons

Pros

• Exceptional heel cushioning that many users find comfortable for walking and long runs.
• Accommodating knit upper that breathes and fits wider feet well.
• Smooth, stable transitions from heel to toe thanks to the tuned midsole geometry.

Cons

• Perceived value varies; some customers find the price high compared with alternatives.
• Sizing reports are mixed, so buyers should confirm fit before committing.

Specifications

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, smooth transitions, and an accommodating fit; its DNA Tuned midsole and medical certifications add practical value. Those needing extra corrective stability or a budget option should look elsewhere, but for neutral-cushion performance and comfort, the Glycerin 22 is worth considering.

Frequently Asked Questions

Do these run true to size?
Sizing reports are mixed among customers, so trying on or ordering multiple sizes for return is recommended if unsure.

Are these good for wide feet?
Yes, the double jacquard knit upper is accommodating and many users with wide feet report a comfortable fit.

Can I use these for walking and running?
Yes, the maximum cushioning and smooth transitions make them suitable for both walking and road running.