Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, high-cushion neutral trainer that prioritizes comfort and smooth transitions. The Glycerin 22 stands out for its updated DNA Tuned midsole that blends large heel cells with smaller forefoot cells for soft landings and responsive toe-offs, and it carries both PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance. For runners and walkers who want maximum cushioning and stable, smooth ride feel, the Glycerin 22 is worth trying.

Key Features

• DNA Tuned Cushion: The midsole combines larger heel cells and smaller forefoot cells to deliver soft heel landings and energetic toe-offs for smoother transitions.
• Neutral Support: Designed as a neutral shoe it provides maximum cushioning without added stability elements, making it versatile for road running and gym use.
• Accommodating Fit: The double jacquard knit upper flexes and breathes, offering a comfortable, adaptable fit while maintaining durability.
• Stable Platform: A broad sole platform and tuned heel and forefoot help stabilize the foot and reduce harsh heel-to-toe jolts for a more controlled stride.
• Medical and Podiatric Approval: Certified PDAC A5500 and carrying the APMA Seal of Acceptance, the shoe is appropriate for users who need validated comfort and foot health considerations.

Who It's For

The Glycerin 22 is best for neutral runners, walkers, and anyone who spends long periods on their feet and values plush cushioning over aggressive responsiveness. It suits road running, cross training, gym routines, and everyday walking where comfort and a smooth ride matter more than minimal weight.

Shoppers who need maximum motion control or rigid stability should look at stability-specific models such as the Glycerin GTS line. Also, people who prefer a very narrow racing fit or ultra-lightweight racing flats may find the Glycerin 22 heavier and more cushioned than necessary.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that many customers describe as very comfortable for long runs and walking.
• Smooth, stable transitions from heel to toe thanks to the tuned midsole and broad platform.
• Breathable, flexible upper that adapts to the foot and holds up well over time.
• Approved by podiatric organizations, offering confidence for foot health concerns.

Cons

• Fit can be inconsistent for some users-some find the shoe narrow while others feel it suits wider feet, so trying on is advised.
• Not a stability shoe; those who require motion control should choose a different model.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit for flexibility and breathability
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, smooth transitions, and a reliable, breathable fit. With podiatric certifications and a tuned midsole, it delivers value for anyone seeking daily comfort and supportive cushioning rather than maximal stability or racing performance.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers consistently report excellent cushioning and heel padding that make the shoe comfortable for walking and extended wear.

Do they run true to size?
Fit reports vary; some find the shoe true to size while others note a narrower feel, so trying on or checking return policy is recommended.

Is this shoe suitable for diabetic foot care?
Yes. The Glycerin 22 is certified PDAC A5500 and carries the APMA Seal of Acceptance, indicating suitability for diabetic foot considerations.