Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning 21

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to buy is the new DNA Tuned midsole, which balances a plush landing and energetic toe-offs through dual-size cells; that central tech delivers noticeably softer heel strikes and more responsive forefoot push-offs compared with the prior Glycerin 21. The shoe is also APMA accepted and PDAC A5500 certified, making it a solid pick for those seeking supportive, comfortable daily footwear.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells create a responsive toe-off for smoother strides.
• Neutral Support: Designed for neutral runners, it offers the maximum amount of cushioning without added corrective structure for a natural ride.
• Accommodating Fit: The double jacquard knit upper flexes with the foot and improves breathability and comfort for long runs or daily wear.
• Smooth Transitions: A broad platform with tuned heel and forefoot geometry stabilizes the foot and smooths heel-to-toe movement.
• Medical Certifications: Certified PDAC A5500 for diabetic use and carries the APMA Seal of Acceptance, supporting foot health concerns.

Who It's For

The Glycerin 22 suits neutral road runners who want plush cushioning and a stable platform for easy daily miles, recovery runs, or long walks. It also appeals to people seeking an APMA-accepted shoe with generous padding around the heel for extra comfort during extended wear.

Runners who need strong motion control or high arch correction should look at support-specific models such as the Glycerin GTS rather than this neutral version. Those who prefer a very narrow, performance race fit may also prefer a different, more snug model.

Pros & Cons

Pros

• Exceptional cushioning that absorbs impact and feels plush during long runs or walks.
• DNA Tuned midsole gives a balanced feel with softer heel landings and energizing forefoot responses.
• Breathable double jacquard knit upper provides a comfortable, accommodating fit for varied foot shapes.
• APMA Seal and PDAC A5500 certification add confidence for users with foot health concerns.

Cons

• Fit reports are mixed; some users with wider feet find it perfect while others find the shoe narrow, so sizing may require trying on.
• As a maximum-cushion neutral shoe, it is not the best choice for runners needing strong stability or corrective support.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Platform	Broad platform for stable transitions
Health Certifications	PDAC A5500 certified, APMA Seal of Acceptance

Our Verdict

The Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, smooth heel-to-toe transitions, and an accommodating knit fit. Its DNA Tuned midsole and health certifications make it a good value for daily training, recovery runs, and anyone prioritizing comfort and foot health, but try sizing if you have particularly wide or narrow feet.

Frequently Asked Questions

Are these shoes good for walking?
Yes. The generous cushioning and stable platform make them comfortable and supportive for long walks and everyday wear.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing added support should consider the Glycerin GTS version for corrective guidance.

How do they fit compared with the previous model?
Fit is similar to the prior Glycerin 21 in most ways, though reports vary and some users find the new knit upper fits more accommodating while others note a narrower feel, so trying them on is advised.