Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning APMA

In this review the Brooks Mens Glycerin 22 Neutral Running Shoe is recommended for runners and walkers who prioritize maximum cushioning and smooth transitions. The main reason to buy is the updated DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver a soft landing and energetic toe-offs, while the certified PDAC A5500 diabetic fit and APMA Seal confirm its comfort and therapeutic credentials. Overall it reads like a premium neutral trainer built for long miles, recovery runs, and everyday use.

Key Features

• DNA Tuned Cushion: The midsole uses dual cell sizing to give a plush heel landing and responsive push from the forefoot for smoother toe-offs.
• Neutral Support: Designed as a neutral shoe with maximum cushioning, it suits road running, gym work, and long walks without added corrective support.
• Accommodating Fit: The double jacquard knit upper stretches to reduce pressure points while keeping breathability and durability where runners need it.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot stabilizes the foot and helps heel-to-toe movement feel consistent.
• Therapeutic Certification: The shoe is a PDAC A5500 certified diabetic shoe and carries the APMA Seal of Acceptance for foot health considerations.

Who It's For

The Glycerin 22 is best for neutral runners who want maximum cushioning for long runs, recovery days, or predominantly road-based training, and for walkers seeking plush daily comfort. Its certification also makes it a good option for buyers who need a more accommodating, foot-health focused shoe.

Those who need firm stability or strong motion control should consider a support model such as the Glycerin GTS 22 instead. Also, runners who prefer an extremely narrow race day fit or a minimal, low-drop trainer may want a lighter, less cushioned option.

Pros & Cons

Pros

• Excellent cushioning and heel padding that many buyers call comfortable for long walks and runs.
• Responsive transitions thanks to the DNA Tuned midsole that balances plush landings with energetic toe-offs.
• Accommodating knit upper that offers breathability and a forgiving fit for foot sensitivity or swollen feet.
• Approved by APMA and certified PDAC A5500, supporting foot health needs.

Cons

• Fit feedback is mixed; some find the shoe narrow while others say it suits wide feet, so sizing can be inconsistent across users.
• Heavily cushioned platform may feel bulky to runners seeking minimal, race-focused footwear.

Specifications

Our Verdict

The Glycerin 22 is a strong choice for runners and walkers who want maximum cushioning with smooth, stable transitions and a forgiving, breathable fit. Its therapeutic certifications add value for anyone needing extra foot comfort, though buyers should check fit carefully if they have very narrow or very wide feet. For cushioned road miles and daily comfort it represents solid value.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers report excellent comfort and cushioning for walking and everyday use, particularly noting the padded heel.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing added support should look at a GTS or stability model.

Should I size up or down?
Sizing feedback is mixed; try your usual running size but consider ordering from a retailer with free returns if you tend to fall between widths.