Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning blends

In this review the Brooks Mens Glycerin 22 Neutral Running Shoe is presented as a top pick for runners and walkers who want maximum cushioning without added stability presses. The bottom line: it delivers exceptionally soft landings and energetic toe-offs thanks to Brooks DNA Tuned midsole technology, and its APMA Seal and PDAC A5500 diabetic certification make it a thoughtful choice for anyone needing extra foot care. Overall the Glycerin 22 is best for neutral runners and everyday wearers who prioritize plush comfort over firm responsiveness.

Key Features

• DNA Tuned Cushion: Larger heel cells provide soft, plush landings while smaller forefoot cells promote responsive toe-offs for smoother transitions.
• Neutral Support: Designed for neutral runners who want maximum cushioning without added pronation control, suitable for road running and gym use.
• Certified Foot Health: The shoe is PDAC A5500 diabetic certified and carries the APMA Seal of Acceptance, indicating care for sensitive feet.
• Accommodating Fit: The double jacquard knit upper offers a flexible, breathable fit that adapts to foot shape while remaining durable.
• Stable Platform: A broad sole platform stabilizes the foot and works with the tuned heel and forefoot to smooth heel-to-toe movement.
• Everyday Versatility: Works well for road running, walking, cross training, and daily wear where cushioning and comfort matter most.

Who It's For

The Glycerin 22 is ideal for neutral runners who want maximum cushioning and a plush ride on roads, treadmill runs, or long walks. It also fits users who need certified diabetic-friendly footwear or who prioritize heel cushioning and overall comfort for extended wear.

Runners seeking strong medial support or motion control should look elsewhere, such as shoes built specifically for overpronation. Also, those who prefer a very narrow, race-oriented fit or extremely firm responsiveness may find this shoe too soft.

Pros & Cons

Pros

• Exceptional cushioning and heel padding improve comfort on long runs and walks.
• DNA Tuned midsole balances plush landings with responsive toe-offs for smoother transitions.
• APMA Seal and PDAC A5500 diabetic certification add confidence for sensitive feet.
• Breathable double jacquard knit upper offers a comfortable, accommodating fit.

Cons

• Fit can be inconsistent for some customers, with reports ranging from perfect for wide feet to feeling narrow, so trying them on is recommended.
• The emphasis on maximum cushioning may feel too soft for runners who want a firmer, race-day shoe.

Specifications

Brand	Brooks
Model	Glycerin 22 (predecessor Glycerin 21)
Support type	Neutral
Midsole	DNA Tuned dual-size cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Best for	Road running, walking, cross training, everyday wear

Our Verdict

The Brooks Glycerin 22 is a strong choice for neutral runners and anyone who values plush cushioning and certified foot care features; its DNA Tuned midsole delivers a comfortable, smooth ride and the accommodating knit upper adds wearability, making it excellent value for long runs and daily walking use.

Frequently Asked Questions

Are these shoes good for diabetic feet?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal, indicating suitability for sensitive or diabetic feet.

Do they run true to size?
Customer reports are mixed on sizing; some find them true or roomy for wide feet while others find them narrow, so fitting before purchase is recommended.

Can I use these for speed training?
They are designed for plush cushioning and smooth transitions rather than lightweight racing, so they are better suited to easy runs, long runs, and walking than fast intervals.