Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning cells

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions. The single biggest reason to buy is the new DNA Tuned midsole that blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, creating a ride that feels both plush and energetic. It also carries the APMA Seal of Acceptance and is certified as a PDAC A5500 Diabetic shoe, which adds confidence for users seeking foot health credentials.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning, making it suitable for road running and everyday training.
• DNA Tuned cushion: Larger heel cells deliver soft, plush landings while smaller forefoot cells encourage responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper adapts to foot shape for comfort and breathability without feeling tight.
• Stable platform: A broad midsole platform stabilizes the foot and supports heel-to-toe motion during longer runs or walks.
• Foot health certifications: Certified PDAC A5500 and APMA accepted, signaling suitability for diabetic and foot-care concerns.

Who It's For

The Glycerin 22 is ideal for neutral runners, walkers, or gym users who want the maximum cushioning available in a road running shoe. It fits well for people with wider feet or those who value a softer heel feel, and customers consistently praise its comfort and heel cushioning for walking and daily miles.

Runners who need strong corrective support or a highly firm, performance-focused race shoe should look elsewhere; the Glycerin GTS 22 is the closer Brooks option for added support. Also, budget shoppers who prioritize low price over plush cushioning may find mixed value opinions among other buyers.

Pros & Cons

Pros

• Exceptional cushioning that absorbs impact, especially at the heel.
• Comfortable, breathable knit upper that accommodates wider feet.
• Smooth, stable transitions from heel to toe due to the tuned midsole geometry.
• Recognized foot-health credentials with PDAC A5500 certification and the APMA Seal.

Cons

• Some buyers note mixed feelings on value for money, as the premium cushioning comes at a higher price point.
• The plush ride may feel too soft for runners seeking a firmer, race-oriented shoe.

Specifications

Model	Glycerin 22
Support type	Neutral
Cushioning tech	DNA Tuned midsole with varied cell sizes
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a top choice for runners and walkers who want maximal plush cushioning, a stable broad platform, and an accommodating fit. Its health-focused certifications and smooth ride justify the price for those who value comfort and foot protection, while performance-focused runners seeking firmer responsiveness may prefer a different model.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers consistently report that the Glycerin 22 is excellent for walking thanks to the plush heel cushioning and stable platform.

Do they fit wide feet?
The double jacquard knit upper provides an accommodating fit that works well for many people with wider feet; customers note a comfortable, breathable feel.

Is this shoe suitable for people with foot health concerns?
Yes. The Glycerin 22 is certified PDAC A5500 and carries the APMA Seal, indicating suitability for diabetic foot needs and general foot health support.