Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning FIT

Our review of the Brooks Mens Glycerin 22 finds it is best for runners and walkers who prioritize maximum cushioning and smooth transitions. The single biggest reason to buy is the DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs while maintaining a neutral platform. Certified as a PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, it also serves anyone needing a comfortable, well-cushioned option for road running, cross training, or extended time on their feet.

Key Features

• Neutral Support: Provides a neutral ride with the maximum level of cushioning, suited for runners who do not need added stability control.
• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot create plush landings and responsive toe-offs for smoother gait transitions.
• Accommodating Fit: The double jacquard knit upper offers flexibility and breathability while fitting a range of foot shapes, including wider feet.
• Smooth, Stable Transitions: A broad platform plus a tuned heel and forefoot keeps the foot steady and promotes heel-to-toe fluidity.
• Medical Acceptance: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance for foot health benefits.

Who It's For

The Glycerin 22 is ideal for neutral runners and walkers who want maximum cushioning for long miles, recovery runs, or all-day comfort. It also suits people with flat feet or wide feet seeking a roomy, accommodating fit and good heel cushioning for walking and road running.

Runners who need strong motion control or structured support should consider Brooks options with support features, while minimalists or racers wanting a lightweight, low-profile shoe should look elsewhere for a firmer, more responsive ride.

Pros & Cons

Pros

• Excellent heel cushioning and overall plush comfort praised by customers for walking and running.
• Accommodating knit upper fits wider feet comfortably and breathes well.
• DNA Tuned midsole balances soft landings with energetic toe-offs for smooth transitions.

Cons

• Some customers find the price high compared with other cushioned trainers.
• Sizing opinions vary among users, so trying on first is recommended if possible.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned dual-size cell cushioning
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Intended use	Road running, cross training, walking

Our Verdict

The Brooks Mens Glycerin 22 is a top pick for anyone who values plush cushioning and smooth ride quality in a neutral trainer. Its DNA Tuned midsole and roomy knit upper make it a comfortable choice for long runs, walking, and daily wear, and the medical certifications add confidence for diabetic or foot-sensitive users. It represents good value if maximum cushioning and foot health acceptance are priorities.

Frequently Asked Questions

Are these shoes good for wide feet?
The accommodating double jacquard knit upper and roomy platform make the Glycerin 22 well suited to wider feet.

Do they provide stability for flat feet?
They offer good support and cushioning for flat feet in a neutral platform, but runners needing corrective motion control should choose a support model.

Do they run true to size?
Customer opinions vary, so trying them on or checking the retailer's return policy is recommended before committing.