Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning GTS
Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning GTS
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Our review of the Brooks Mens Glycerin 22 finds it geared toward runners and walkers who prioritize maximum cushioning and a smooth ride. The standout reason to buy is the updated DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft landings and responsive toe-offs, giving long runs and long walks a plush, effortless feel. It is also notable for having APMA acceptance and PDAC A5500 diabetic certification, which reinforces its focus on comfort and foot health.
Key Features
- Neutral support: Provides a neutral platform with the maximum amount of cushioning for road running, cross training, and daily walking.
- DNA Tuned cushion: Larger cells in the heel and smaller cells in the forefoot balance plush landings with energetic toe-offs for smoother transitions.
- Accommodating fit: The double jacquard knit upper stretches to adapt to foot shape while maintaining breathability and durability for long wear.
- Smooth, stable transitions: A broad platform and tuned heel and forefoot stabilize the foot through heel-to-toe motion for confident strides.
- Clinical approvals: Certified PDAC A5500 and granted the APMA Seal of Acceptance, indicating suitability for people who need extra foot care and cushioning.
Who It's For
This shoe is best for neutral runners and walkers who want maximum cushioning underfoot and a stable, plush ride for road miles or extended walks. The Glycerin 22 is a strong choice for gym-goers who prefer a soft landing during cross training and for anyone who values heel padding and long-wear comfort.
Those who need firm motion control or strong pronation correction should look elsewhere, such as a stability model, because the Glycerin 22 is built as a neutral shoe. Also, buyers with very wide feet should try them on first, as some customers report a narrower fit despite the accommodating knit upper.
Pros & Cons
Pros
- Exceptional cushioning and heel padding that reduce impact on long runs and walks.
- DNA Tuned midsole balances plush landings with responsive toe-offs for smooth transitions.
- Accommodating knit upper combines breathability and a flexible fit for daily wear.
- APMA Seal and PDAC A5500 certification support foot-health credentials.
Cons
- Some users find the fit narrow, so they may need to try different widths or sizes.
- Neutral design means it is not ideal for runners who require added motion control.
Specifications
| Model | Glycerin 22 |
| Support type | Neutral |
| Midsole technology | DNA Tuned with dual-size cells |
| Upper | Double jacquard knit |
| Certifications | APMA Seal of Acceptance; PDAC A5500 diabetic shoe |
| Ideal use | Road running, cross training, walking |
Our Verdict
The Brooks Mens Glycerin 22 is a top pick for runners and walkers seeking maximum cushioning, smooth transitions, and foot-health credentials, making it good value for anyone who prioritizes comfort and long-wear support. Try sizing for width if you have broader feet, but for neutral runners the Glycerin 22 delivers plush, reliable performance.
Frequently Asked Questions
Are these shoes good for walking?
Yes. Customers repeatedly note the strong cushioning and heel padding make long walks feel effortless and comfortable.
Do they offer stability for overpronation?
No. The Glycerin 22 is a neutral shoe; choose a stability model like the Glycerin GTS or a dedicated stability trainer for overpronation.
How does the fit run?
Fit is generally true to size for many, but some users find the shoe narrow, so trying the shoe on or checking width options is recommended.
Editor's Take
The Brooks Mens Glycerin 22 is ideal for runners and walkers who want maximum cushioning and smooth transitions; its DNA Tuned midsole and clinical certifications deliver plush comfort and reliable daily performance.

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