Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning IS

Our review of the Brooks Mens Glycerin 22 finds a neutral daily trainer best for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to buy is the updated DNA Tuned midsole, which blends dual-size cells for a plush heel landing and responsive toe-off, delivering a soft ride without feeling sloppy. Certified as a PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, the Glycerin 22 is also a reliable option for anyone seeking extra underfoot comfort for long days on their feet.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller cells in the forefoot create soft landings and energetic toe-offs for smoother gait cycles.
• Neutral Support: Provides a neutral platform with the maximum amount of cushioning, suitable for road running, cross training, or everyday walking.
• Accommodating Fit: The double jacquard knit upper offers flexible, breathable coverage that adapts to the foot while remaining durable.
• Smooth Transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and smooth heel-to-toe movement.
• Medical Acceptance: Certified PDAC A5500 and APMA-accepted, indicating suitability for users who need footwear with validated comfort and support.

Who It's For

The Glycerin 22 is aimed at neutral runners and active walkers who want maximum cushioning for longer runs, recovery days, or all-day comfort. It is especially appealing to people with heel sensitivity or those who appreciate a plush landing combined with a responsive forefoot for easy toe-offs.

Those who need structured stability or aggressive motion control should look elsewhere, such as a model with built-in support or medial posting. Also, buyers who require a very narrow race fit may find the accommodating knit upper too roomy; try a model designed specifically for performance racing instead.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that many customers praised for comfort during runs and all-day wear.
• Smooth, stable transitions thanks to the broad platform and tuned midsole geometry.
• Breathable, flexible knit upper that adapts to the foot and improves overall comfort.

Cons

• Fit is inconsistent for some buyers-some find it perfect for wider feet while others report a narrow feel, so sizing may require trying on first.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Medical Certification	PDAC A5500; APMA Seal of Acceptance

Our Verdict

The Glycerin 22 is a top choice for runners and walkers who want plush cushioning and smooth ride dynamics in a neutral shoe. With its DNA Tuned midsole and accommodating knit upper it delivers comfort and stability for road miles and daily wear, making it good value for anyone prioritizing cushioning and foot health.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers consistently report excellent comfort and cushioning that makes the Glycerin 22 comfortable for walking and everyday use.

Do they offer support for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing added support should consider a stability or guidance-track model.

Do they run true to size?
Fit varies by foot shape-some users find a true fit, others report a narrower feel, so trying them on or checking return options is recommended.