Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning Look

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum, plush cushioning with smooth transitions. The Glycerin 22 uses Brooks DNA Tuned midsole technology to blend larger heel cells and smaller forefoot cells for soft landings and energetic toe-offs, and it carries both PDAC A5500 diabetic certification and the APMA Seal of Acceptance. For anyone prioritizing comfort, cushioning and stable road performance, the Glycerin 22 delivers a clearly noticeable step-up from its predecessor.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells create a responsive toe-off for smoother transitions.
• Neutral Support: Designed for neutral runners, the shoe offers the maximum amount of cushioning without added stability posts, making it versatile for road runs, gym sessions, and walking.
• Accommodating Fit: The double jacquard knit upper flexes and breathes while maintaining durability, adapting to foot shape for all-day comfort.
• Smooth, Stable Platform: A broader platform stabilizes the foot and, together with the tuned heel and forefoot, smooths heel-to-toe motion.
• Medical & Podiatric Acceptance: Certified PDAC A5500 and granted the APMA Seal of Acceptance, indicating suitability for users needing extra foot care considerations.

Who It's For

The Glycerin 22 is best for neutral road runners and frequent walkers who value plush cushioning and smooth transitions over aggressive responsiveness. It is a strong choice for daily training runs, long walks, cross training, or anyone who spends long hours on their feet and wants protective padding, especially where heel cushioning matters.

Runners who need pronounced stability or corrective support should look at a guided-stability option instead, and those seeking an ultra-light, racing-style shoe will find the Glycerin 22 heavier and more cushion-focused than minimal performance models.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that reduces impact during runs and walking.
• Comfortable, breathable knit upper that adapts to the foot for everyday wear.
• Certified PDAC A5500 and carries the APMA Seal of Acceptance, reassuring for users with foot-care needs.
• Broad platform and tuned midsole promote smooth, stable heel-to-toe transitions.

Cons

• Fit varies among customers; some find it narrow while others report it suits wide feet, so trying for fit is advised.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic approved; APMA Seal of Acceptance

Our Verdict

The Brooks Glycerin 22 is a top pick for runners and walkers who prioritize luxurious cushioning and a smooth ride; its DNA Tuned midsole and broad platform balance comfort and stability, and the medical certifications add value for foot-care needs. Try a fitting first if you are between widths, but for most neutral runners this is a comfortable, high-quality daily trainer.

Frequently Asked Questions

Are these shoes suitable for long daily walks?
Yes. The plush midsole cushioning and stable platform make the Glycerin 22 well suited to long walks and all-day wear.

Do these run true to size?
Customer reports vary; some say they fit true to size while others find them narrow, so trying them on or ordering two sizes to compare is recommended.

Is this shoe appropriate for diabetic foot care?
Yes. The Glycerin 22 is PDAC A5500 certified and has the APMA Seal of Acceptance, indicating it meets standards often recommended for diabetic foot care.