Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning PDAC

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a high-cushion neutral trainer built for runners and walkers who prioritize comfort and smooth transitions. The standout reason to buy is the updated DNA Tuned midsole that blends larger heel cells with smaller forefoot cells, delivering soft landings and responsive toe-offs while maintaining a broad, stable platform. It also carries certification as a PDAC A5500 diabetic shoe and the APMA Seal of Acceptance, which reinforces the focus on foot health and long-wear comfort.

Key Features

• DNA Tuned Cushion: Larger cells in the heel deliver plush, shock-absorbing landings while smaller forefoot cells provide a responsive toe-off for a balanced ride.
• Neutral Support: Designed as a neutral shoe, it supplies maximum cushioning without built-in corrective motion control, making it versatile for road runs and gym sessions.
• Accommodating Fit: The double jacquard knit upper offers flexibility and breathability while adapting well to slightly wider feet and long walks.
• Smooth Transitions: A tuned heel and forefoot combined with a broad platform stabilize the foot and promote even heel-to-toe movement.
• Health Certifications: Certified as a PDAC A5500 diabetic shoe and awarded the APMA Seal of Acceptance, indicating attention to foot health and supportive construction.

Who It's For

The Glycerin 22 is ideal for runners and walkers who want maximum cushioning in a neutral shoe and who value smooth heel-to-toe transitions. Its accommodating knit upper and broad platform make it especially suitable for people with wider feet or those who take longer daily walks and want reliable heel cushioning.

It is less tailored to runners who need strong corrective support; athletes requiring firm stability or motion control should look at the Glycerin GTS or dedicated stability models. Those seeking a minimalist, low-stack shoe should also consider lighter alternatives.

Pros & Cons

Pros

• Exceptionally comfortable heel cushioning that performs well on long walks and runs.
• Broad, stable platform and tuned transitions that reduce harsh heel strikes.
• Accommodating knit upper provides breathability and a flexible fit for wider feet.
• Useful health certifications for diabetic users and general foot care assurance.

Cons

• As a maximal-cushion neutral shoe, it may feel too soft for runners seeking firm, responsive rides.
• Value impressions are mixed among customers, with some expecting different performance for the price.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned dual-cell midsole
Upper	Double jacquard knit, breathable and flexible
Health Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, stable transitions, and an accommodating fit. Its DNA Tuned midsole and health certifications add real value for users needing extra heel cushioning or diabetic-friendly footwear. Those who want firmer responsiveness or heavy stability features should consider alternatives, but for comfort-focused neutral running and everyday walking the Glycerin 22 is worth considering.

Frequently Asked Questions

Are these shoes good for wide feet?
Yes; the double jacquard knit upper is flexible and accommodating, and customers report a comfortable fit for slightly wider feet.

Do they provide stability for flat feet?
They offer good cushioning and support that helps many with flat feet, but they are neutral shoes; those needing corrective stability should try the Glycerin GTS line.

Can they be used for walking long distances?
Yes; customers note excellent heel cushioning and comfort on long walks, with one report of suitability for 6-mile walks.