Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning Road

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prize maximum cushioning and smooth transitions. The standout reason to consider these shoes is the upgraded DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft landings and energetic toe-offs, making long runs and all-day wear noticeably gentler on the feet. The Glycerin 22 also carries APMA acceptance and PDAC A5500 diabetic certification, which reinforces its suitability for people seeking extra foot comfort and protection.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning for road running, cross training and everyday walking.
• DNA Tuned cushion: Larger heel cells give plush landings while smaller forefoot cells create more responsive toe-offs to smooth gait transitions.
• Accommodating fit: A double jacquard knit upper stretches where needed for wide or fuller feet while maintaining breathability and durability.
• Smooth, stable transitions: A broad midsole platform and tuned heel/forefoot encourage stable heel-to-toe roll without feeling clunky.
• Medical endorsements: Certified PDAC A5500 and APMA Seal of Acceptance, which supports use for foot health and diabetic needs.

Who It's For

The Glycerin 22 is aimed at neutral runners who want maximum cushioning for long road miles, runners transitioning from the Glycerin 21, and walkers who need supportive, cushioned shoes for extended wear. It is also a good choice for people with wider feet thanks to the accommodating knit upper and those who value footwear with APMA and PDAC certifications.

Runners who need strong motion control or personalized stability should look at the Glycerin GTS 22 version with added support, while minimalists seeking a low-profile responsive ride may prefer a less cushioned, lighter model.

Pros & Cons

Pros

• Exceptional heel cushioning that customers frequently praise for walking and running comfort.
• Broad, stable platform that improves balance and smooths transitions from heel to toe.
• Accommodating double jacquard knit upper works well for wide feet and long wear.

Cons

• Some buyers find the price on the higher side compared with basic trainers.
• Fit opinions vary, so sizing may require trying on to confirm true-to-size for some users.

Specifications

Model	Glycerin 22
Support	Neutral
Cushion Technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit for flexibility and breathability
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Ideal use	Road running, walking, cross training

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, stable transitions, and an accommodating fit. Its medical endorsements add confidence for users concerned with foot health, and while it sits at a premium price point, the combination of comfort and durability makes it a worthwhile investment for people who log many miles or need extra protection for the heel and forefoot.

Frequently Asked Questions

Are these shoes good for wide feet?
The double jacquard knit upper is designed to be accommodating and customers frequently report they work well for wider feet.

Do they provide stability for flat feet?
They offer a broad, stable platform and good support for many with flat feet, though those needing firmer stability should consider the Glycerin GTS 22.

Do they run true to size?
Customers disagree on sizing, so trying on or checking the retailer's return policy is recommended when ordering.