Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning Seal

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a premium, neutral-cushion road shoe built for runners and walkers who prioritize plush comfort and smooth transitions. The Glycerin 22 stands out because its DNA Tuned midsole blends larger heel cells with smaller forefoot cells to deliver exceptionally soft landings and responsive toe-offs, making long miles and daily walks feel noticeably less fatiguing. It is also certified for diabetic use and carries the APMA Seal of Acceptance, an important detail for buyers seeking foot-friendly features.

Key Features

• DNA Tuned Cushion: Larger heel cells create soft, plush landings while smaller forefoot cells provide a snappy, energy-returning toe-off for smoother running.
• Neutral Support: Designed as a neutral shoe that provides the maximum amount of cushioning without added stability elements, suited for varied activities from road miles to gym sessions.
• Accommodating Fit: A double jacquard knit upper stretches to fit a range of foot shapes while remaining breathable and durable during extended wear.
• Smooth Transitions: The broad platform and tuned heel-to-toe geometry stabilize the foot and reduce harsh gait changes for steadier rides through each stride.
• Medical Acceptances: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, offering reassurance for shoppers with foot health concerns.

Who It's For

The Glycerin 22 is best for neutral runners, daily walkers, and anyone who wants maximum cushioning underfoot without corrective support. It is particularly appealing to people with wide or accommodating feet who value a plush heel and a comfortable forefoot for longer sessions, and to those who appreciate footwear with medical certifications for diabetic and podiatric considerations.

Those who need strong corrective guidance for severe overpronation should look at stability models rather than this neutral shoe, and runners who prefer minimal, responsive racers may find the abundant cushioning too soft for interval work or tempo racing.

Pros & Cons

Pros

• Exceptional heel cushioning and comfortable ride for long walks and runs.
• Accommodating knit upper fits wider feet and increases everyday comfort.
• APMA and PDAC A5500 acceptances provide confidence for foot health needs.
• Broad platform and DNA Tuned midsole deliver smooth, stable transitions.

Cons

• The very plush cushioning may feel less responsive for faster tempo runs or racers seeking a firmer ride.
• Some buyers report mixed impressions of value versus price, so it may not suit budget-focused shoppers.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with varied cell sizes
Upper	Double jacquard knit, breathable and accommodating
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Glycerin 22 is a top choice for runners and walkers who want maximum cushioning, an accommodating fit, and proven foot-health credentials. Its DNA Tuned midsole and broad platform create a very comfortable daily trainer ideal for long miles and recovery runs; just be aware that the plush ride may not satisfy runners seeking a firm, race-oriented shoe.

Frequently Asked Questions

Are these shoes good for wide feet?
Yes. The double jacquard knit upper stretches and accommodates wider foot shapes while maintaining breathability.

Is the Glycerin 22 a stability shoe?
No. The Glycerin 22 is a neutral-support shoe offering maximum cushioning rather than targeted corrective support; consider Glycerin GTS models for added stability.

Do these shoes suit walking long distances?
Yes. Customers report excellent cushioning and support for extended walks, with particular comfort in the heel area for multi-mile outings.