Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning Shoes

In this review the Brooks Mens Glycerin 22 earns a recommendation for runners and walkers who prioritize plush, consistent cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells with smaller forefoot cells to deliver soft landings and responsive toe-offs while maintaining a notably broad, stable platform. This model is also APMA accepted and PDAC A5500 certified, which adds confidence for people seeking an accommodating, health-conscious daily trainer.

Key Features

• Neutral support: Provides a neutral ride with maximum cushioning ideal for road running, gym sessions, and everyday walking without added corrective medial support.
• DNA Tuned cushion: Larger cells in the heel and smaller cells in the forefoot offer plush landings and energetic toe-offs for smoother gait transitions.
• Accommodating fit: The double jacquard knit upper stretches and breathes to reduce pressure points while remaining durable for regular use.
• Smooth stability: A broad platform and tuned heel-to-toe geometry stabilize the foot for confident heel-to-toe rollovers.
• Health certifications: PDAC A5500 diabetic shoe certification and the APMA Seal of Acceptance provide added reassurance for foot health and clinical compatibility.

Who It's For

The Glycerin 22 is best for neutral runners and walkers who want maximum cushioning without the guidance or added support of a stability shoe; it works well as a road running trainer and a comfortable option for extended periods on foot. The plush midsole and stable base make it a good choice for daily trainers, people who walk a lot, and those seeking shoes cleared for diabetic foot care.

Runners who need firm, low-profile responsiveness or aggressive stability features should look elsewhere-this shoe favors softness and a bulky, cushioned feel rather than a minimal, race-day ride. Also, shoppers seeking a specifically wider or narrower fit should read user fit notes carefully, as experiences vary.

Pros & Cons

Pros

• Exceptional cushioning and heel padding that many reviewers find comfortable for long walks and runs.
• Stable, broad platform that smooths heel-to-toe transitions for a confident stride.
• Accommodating knit upper provides breathability and a flexible fit when breaking in.
• Certified PDAC A5500 and APMA Seal add practical value for foot health needs.

Cons

• Fit can be inconsistent between users-some report a narrow feel while others find it perfect for wider feet, so trying on is recommended.
• Bulky, ultra-cushioned ride may not suit runners who prefer minimal, race-oriented shoes.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a strong pick for neutral runners and everyday walkers who value maximum cushioning and a smooth ride; its DNA Tuned midsole and stable platform make it good long-mile and all-day footwear, and the health certifications add practical value. Try them on if you have unusual width needs, but if plush comfort and stable transitions are your priority, this shoe is good value.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Many users praise the cushioning and heel padding, making the Glycerin 22 comfortable for long walks and daily wear.

Do they provide motion control or stability?
No. The Glycerin 22 is a neutral-support shoe; choose Glycerin GTS or a stability model if you need added corrective support.

How do they fit?
Fit varies: some find them roomy for wider feet while others find them narrow, so trying them on or checking return options is advisable.