Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning soft

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout is the DNA Tuned midsole, which blends larger heel cells with smaller forefoot cells to deliver plush landings and responsive toe-offs, making long runs and all-day wear comfortable. As a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, it also suits buyers seeking validated foot health features without sacrificing the luxury feel of a high-cushion neutral trainer.

Key Features

• Neutral support: Provides neutral guidance while offering the maximum amount of cushioning for road running and everyday use.
• DNA Tuned cushion: Larger midsole cells in the heel create soft landings while smaller forefoot cells invite energetic toe-offs.
• Accommodating fit: The double jacquard knit upper delivers a flexible, breathable fit that adapts to the foot during activity.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry stabilize the foot and smooth heel-to-toe movement.
• Certified health features: Rated PDAC A5500 for diabetic footwear and awarded the APMA Seal of Acceptance for foot health considerations.

Who It's For

The Glycerin 22 is aimed at neutral runners, walkers, and gym-goers who want high levels of cushion and a forgiving ride for long distances or daily wear. Its certification for diabetic patients and APMA approval also make it appealing to users who need validated foot-care footwear with soft heel padding and stable platforms.

Runners who need strong corrective support should consider the Glycerin GTS 22 instead, since the Glycerin 22 is neutral. Also, those who require a distinctly narrow or very wide last may want to try them on first, as customer reports vary on fit and some find the width inconsistent.

Pros & Cons

Pros

• Exceptional cushioning and plush heel feel that reduce impact on long runs and walks.
• Stable, broad platform that promotes smooth heel-to-toe transitions.
• Breathable, accommodating knit upper that balances durability and comfort.
• Health-focused certifications (PDAC A5500 and APMA Seal) that support foot-care use.

Cons

• Fit can be inconsistent for some customers; some report narrowness while others praise the fit for wider feet.
• As a maximum-cushion neutral shoe, it may not suit runners who need pronounced stability or motion control.

Specifications

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and everyday walkers who want maximum cushioning, validated foot-health features, and a smooth, stable ride. It represents good value for buyers seeking plush comfort and supportive transitions, though those needing targeted stability or a very specific fit should try before buying.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers frequently praise the cushioning and heel padding, making the Glycerin 22 comfortable for walking and daily wear.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; runners needing added support should look at the Glycerin GTS 22.

Do they run true to size?
Fit reports vary; some customers find them true or roomy for wide feet while others find them narrow, so trying them on or checking return options is recommended.