Brooks Mens Glycerin 22 Neutral Running Shoe - Plush Cushioning take

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to buy is the updated DNA Tuned midsole, which uses dual-size cells to deliver soft heel landings and responsive toe-offs, producing a noticeably plush yet energetic ride. Certified as a PDAC A5500 Diabetic shoe and carrying the APMA Seal of Acceptance, the Glycerin 22 also comforts sensitive or wider feet while remaining neutral enough for road running, gym sessions, and everyday walking.

Key Features

• DNA Tuned Cushion: Larger heel cells provide plush landings while smaller forefoot cells encourage a springy toe-off for balanced transitions.
• Neutral Support: Offers maximal cushioning without added motion control, ideal for neutral runners and walkers seeking comfort.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to fit a range of foot shapes, including wider feet.
• Smooth Transitions: A broad platform and tuned heel/forefoot work together to stabilize the foot and smooth heel-to-toe movement.
• Medical Acceptance: Certified PDAC A5500 and APMA accepted, making it a sound option for users needing protective, foot-friendly footwear.

Who It's For

The Glycerin 22 suits men who want the maximum amount of cushioning in a neutral running shoe: road runners logging longer easy miles, walkers who prioritize underfoot comfort, and people with flat or wider feet who need a roomy, supportive platform. Its medical certifications also make it attractive to those needing footwear acceptable for certain diabetic or foot-care programs.

Runners who require pronounced stability or corrective support should look at other models, such as the Glycerin GTS version for added guidance. Those seeking a minimal, highly responsive race shoe will find the plush Glycerin 22 heavier and softer than performance racing options.

Pros & Cons

Pros

• Exceptional plush cushioning that excels on long easy runs and walking.
• Accommodating knit upper that fits wider feet comfortably.
• Stable, broad platform that smooths heel-to-toe transitions.
• Medical certifications (PDAC A5500 and APMA) that support foot health concerns.

Cons

• Some buyers note inconsistent sizing, so trying on or checking fit guidance is advised.
• The highly cushioned feel may be too soft for runners who prefer firm, race-oriented responsiveness.

Specifications

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who want the most cushioning in a neutral platform coupled with a roomy, comfortable fit. Its DNA Tuned midsole and stable broad base deliver smooth, plush rides that justify the price for those prioritizing comfort and foot health; buyers seeking firmer, faster shoes should consider alternatives.

Frequently Asked Questions

Do these run true to size?
Customers report mixed sizing experiences, so it's wise to try them on or consult the retailer's size guide before ordering.

Are they good for wide feet?
Yes, the double jacquard knit upper is accommodating and many users with wider feet find the fit comfortable.

Can I use them for walking and running?
Yes, the neutral support and maximum cushioning make them suitable for both walking and road running.