Brooks Mens Glycerin 22 Neutral Running Shoe - Plush, Smooth Ride

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a highly cushioned, comfortable neutral trainer best for runners and walkers who prioritize plush landings and smooth transitions. The Glycerin 22 stands out for its DNA Tuned midsole that blends large heel cells with smaller forefoot cells to deliver soft heel strikes and energetic toe-offs, while also carrying PDAC A5500 diabetic certification and the APMA Seal of Acceptance for foot health.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells encourage responsive toe-offs for forward momentum.
• Neutral Support: Designed as a neutral shoe that offers the maximum amount of cushioning without added stability posts, suitable for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper flexes with the foot for breathability and a comfortable hoop-like feel that adapts to foot shape during runs.
• Smooth Transitions: A broad platform and tuned heel-to-forefoot geometry stabilizes the foot and smooths heel-to-toe movement on road surfaces.
• Foot Health Approvals: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, indicating suitability for users needing therapeutic or diabetic footwear features.

Who It's For

The Glycerin 22 is a strong choice for road runners, daily walkers, and gym users who want maximum cushioning and a plush ride without added motion-control elements. Runners recovering from mild foot soreness or those who value heel and forefoot protection will appreciate the soft landings and supportive platform.

Those who need aggressive stability, minimal cushioning, or a very narrow racing fit should look elsewhere; runners who require a rigid corrective last or a heavy stability shoe will find the Glycerin 22 too soft and too focused on cushioning rather than firm control.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact and feels comfortable on long walks and runs.
• Broad platform and tuned transitions deliver stable, smooth heel-to-toe movement.
• Accommodating knit upper offers breathable comfort and holds its shape well during activity.
• PDAC A5500 certification and APMA Seal support use for users with foot-health concerns.

Cons

• Fit is inconsistent across users; some find it narrow while others report it fits wide feet well, so trying on or checking return options is advised.
• Neutral design may not provide enough support for severe overpronation or runners who need structured stability.

Specifications

Brand	Brooks
Model	Glycerin 22
Support	Neutral
Midsole Tech	DNA Tuned with varied cell sizes
Upper	Double jacquard knit
Certifications	PDAC A5500 certified; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is worth buying for runners and walkers who want maximum cushioning, smooth transitions, and a comfortable, breathable fit. It provides excellent value for anyone needing plush daily trainers or therapeutic-friendly footwear, though shoppers with stability needs or uncertain fit should verify sizing before committing.

Frequently Asked Questions

Are these shoes good for walking?
Yes, customers frequently praise the Glycerin 22 for walking comfort thanks to its cushioning and stable platform.

Do they run true to size?
Fit reports vary; some users find them true to size while others see a narrower fit, so try them on or confirm the store return policy.

Is this shoe suitable for diabetic feet?
Yes, it is PDAC A5500 certified and has the APMA Seal, indicating it meets criteria for therapeutic or diabetic-friendly footwear.