Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style 542Y)

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a high-cushion, road-friendly trainer for runners and walkers who prioritize a soft, responsive ride and a comfortable fit. The standout reason to buy is the updated DNA Tuned midsole that blends large heel cells with smaller forefoot cells for plush landings and lively toe-offs, while certifications like PDAC A5500 and the APMA Seal underline its suitability for foot health and long wear.

Key Features

• DNA Tuned Cushion: Dual-size midsole cells are arranged to give a soft, protected heel strike and an energetic, responsive toe-off for smoother transitions.
• Neutral Support: Designed for neutral runners, it provides maximum cushioning without added stability posts, making it versatile for road runs and gym sessions.
• Accommodating Fit: The double jacquard knit upper stretches where needed, offering breathability and a forgiving fit across the forefoot.
• Smooth Transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and reduces abrupt heel-to-toe movement.
• Professional Certifications: Certified PDAC A5500 for diabetic footwear and approved by the APMA, indicating attention to foot health and long-term comfort.

Who It's For

The Glycerin 22 is best for neutral runners and walkers who want maximum cushioning for road miles, long walks, or everyday wear. It works well for gym sessions and cross training where a plush, stable platform is preferred over a performance racer feel.

Runners seeking strong corrective support should look at stability variants like the Glycerin GTS 22 instead, and those wanting an ultralight race shoe or minimal heel-to-toe drop should consider purpose-built trainers with a firmer, lower-profile midsole.

Pros & Cons

Pros

• Excellent cushioning and heel padding that customers consistently praise for comfort during runs and long walks.
• Breathable, flexible double jacquard knit upper that adapts to the foot for a more comfortable fit.
• Stable, broad platform and tuned midsole deliver smooth, confident heel-to-toe transitions.
• Certified PDAC A5500 and APMA Seal of Acceptance, which supports its use for foot health and diabetic-friendly wear.

Cons

• Fit can be inconsistent across customers; some report the shoe runs narrow while others find it roomy, so trying on before committing is advisable.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable
Certifications	PDAC A5500 Diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Mens Glycerin 22 is a solid choice for anyone who wants maximum cushioning and smooth transitions for road running or everyday walking. With a plush DNA Tuned midsole, a breathable knit upper, and credible medical certifications, it offers strong value for runners prioritizing comfort over minimalism or aggressive stability.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Customers consistently report excellent cushioning and heel padding that make the Glycerin 22 comfortable for extended walking and daily wear.

Do they provide support for overpronation?
No. This is a neutral shoe; runners who need corrective support should consider the Glycerin GTS 22 or other stability models.

Do they run true to size?
Fit varies by foot shape-some wearers find them wide enough while others describe a narrow fit, so trying them on or checking return options is recommended.