Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style B343)

In this review the Brooks Mens Glycerin 22 Neutral Running Shoe is presented as a top choice for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole that blends larger heel cells and smaller forefoot cells for soft landings and responsive toe-offs, giving a balanced, comfortable ride whether on the road or on long walks. It also carries both PDAC A5500 diabetic certification and the APMA Seal of Acceptance, which supports its use for customers needing foot-friendly footwear.

Key Features

• Neutral support: Provides maximum cushioning with a neutral platform that suits road running, cross training, and everyday walking without added pronation control.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot deliver plush landings and energetic toe-offs for smoother gait transitions.
• Accommodating fit: The double jacquard knit upper stretches and breathes to reduce hotspots while maintaining durability for repeated use.
• Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and eases heel-to-toe movement.
• Medical-friendly: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, indicating suitability for users who need shoes approved for foot health.

Who It's For

The Glycerin 22 is best for neutral runners and active walkers who want maximum cushioning and a plush underfoot feel without motion-control elements. It works well for longer road runs, recovery miles, gym sessions, and daily wear where comfort and cushioning are priorities. The diabetic certification also makes it a sensible option for customers seeking foot-friendly features backed by recognized approval.

Runners who need firm stability or corrective support should look at models with guidance or support technology, such as the Glycerin GTS line for added support. Also, buyers who require a consistently narrow or very wide fit should try them on first, as customer reports vary on how they fit across foot shapes.

Pros & Cons

Pros

• Excellent cushioning and plush heel feel that reduces impact on longer runs and walks.
• Comfortable, breathable double jacquard knit upper that adapts to foot shape while remaining durable.
• Certified PDAC A5500 and APMA-accepted for users prioritizing foot health.
• Smooth, stable transitions aided by a broad platform and tuned midsole design.

Cons

• Fit varies by customer; some report a narrow feel while others find it suitable for wider feet, so try before committing online if possible.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 Diabetic, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Glycerin 22 is a strong pick for neutral runners and walkers who value a plush, cushioned ride and foot-friendly credentials. Its DNA Tuned midsole and broad platform create smooth, stable transitions, and the diabetic and APMA approvals add practical value for users needing certified comfort. Try them on if you are between widths, but for most people who want maximum cushioning the Glycerin 22 is a worthwhile investment.

Frequently Asked Questions

Are these shoes good for walking?
Yes. The plush cushioning and broad platform make the Glycerin 22 particularly comfortable for walking and everyday wear.

Do they provide support for overpronation?
No. The Glycerin 22 is a neutral shoe; choose the Glycerin GTS version if you need added support for pronation control.

How do they fit?
Fit reports vary: some users find them roomy for wide feet while others find them narrow, so trying them on or checking the retailer's fit guidance is recommended.