Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style FS67)

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum, plush cushioning with smooth transitions. The Glycerin 22 stands out because its DNA Tuned midsole blends large heel cells and smaller forefoot cells for a balance of soft landings and responsive toe-offs, and it is also certified as a PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, which reinforces its comfort and medical-friendly fit. Overall it is a neutral shoe built for everyday road miles, cross training, or extended walking where cushioning and a stable platform matter.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel give soft, plush landings while smaller forefoot cells create more responsive toe-offs for a smoother gait.
• Neutral Support: Designed as a neutral running shoe that provides the maximum amount of cushioning without added corrective support, suitable for a wide range of runners.
• Accommodating Fit: The double jacquard knit upper flexes and breathes while accommodating wider feet and reducing friction points during longer wear.
• Smooth, Stable Transitions: A broad platform and tuned heel/forefoot construction stabilize the foot and ease heel-to-toe movement on road surfaces.
• Medical and Quality Certifications: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, indicating suitability for diabetic and podiatric concerns.

Who It's For

The Glycerin 22 is best for neutral runners, daily walkers, and gym-goers who prioritize cushioning and a plush ride over maximal responsiveness. It is especially well suited to people with flat feet who still prefer a neutral shoe and to anyone who needs a roomier toe box or extra heel cushioning for longer sessions on pavement.

Runners who require strong stability features or corrective motion control should look elsewhere, such as models with built-in guidance or medial support. Those seeking an ultralight racer or a minimalist shoe will also find the Glycerin 22 heavier and more cushioned than they need.

Pros & Cons

Pros

• Exceptional heel cushioning and overall plush comfort for walking and road running.
• Accommodating knit upper offers breathable, flexible fit that suits wider feet.
• Stable broad platform and tuned midsole deliver smooth heel-to-toe transitions.
• Certified PDAC A5500 and APMA Seal of Acceptance for medical-friendly use.

Cons

• Some buyers report inconsistent sizing, so trying on or checking fit guidance is recommended.
• The maximum cushioning focus may feel heavy or less responsive for tempo runs.

Specifications

Our Verdict

The Brooks Mens Glycerin 22 is a compelling choice for runners and walkers who need maximum cushioning, a roomy fit, and stable transitions on pavement. Its DNA Tuned midsole and accommodating knit upper deliver dependable comfort and support for everyday miles, and the medical certifications add confidence for users with foot health concerns. It represents good value for anyone prioritizing plush comfort over race-day speed.

Frequently Asked Questions

Do these run true to size?
Customers report mixed feedback on sizing; trying them on or following Brooks size guidance is recommended for best fit.

Are these shoes good for flat feet?
Yes, the plush cushioning and broad platform provide supportive comfort that many with flat feet find helpful, though they remain a neutral shoe.

Can I use them for walking and gym workouts?
Yes, the Glycerin 22 suits walking, road running, and cross training where cushioning and stability on flat surfaces are priorities.