Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style FX88)

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want maximum soft cushioning with smooth transitions. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver plush landings and energetic toe-offs. It is a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, making comfort and foot health central to its appeal for everyday wear and longer road runs.

Key Features

• DNA Tuned Cushion: Larger heel cells provide soft, plush landings while smaller forefoot cells deliver responsive toe-offs for a balanced ride.
• Neutral Support: Designed for neutral runners who want the maximum amount of cushioning without built-in stability elements.
• Accommodating Fit: The double jacquard knit upper offers flexible, breathable coverage that adapts to the foot for comfort during long use.
• Smooth Transitions: A broad platform and a tuned heel and forefoot stabilize the foot and smooth heel-to-toe motion for consistent road running.
• Medical Acceptance: Certified PDAC A5500 and APMA accepted, indicating suitability for diabetic foot care and everyday foot health.

Who It's For

The Glycerin 22 is best for runners and walkers who prioritize plush cushioning and a smooth ride on roads, treadmills, or around town. It suits neutral gait runners, those who need extra padding for longer walks, and people seeking a shoe with certified diabetic-friendly features.

Shoppers who need pronounced stability or motion control should look at supportive variants like the Glycerin GTS for added guidance. Also, buyers who require a very wide toe box may want to try on this shoe first, as customer feedback on width is mixed.

Pros & Cons

Pros

• Excellent cushioning that reduces impact and feels very comfortable for long walks and runs.
• High-quality construction and padding around the heel that customers cite as noticeably supportive.
• Certified PDAC A5500 and APMA Seal of Acceptance for foot health confidence.
• Breathable, accommodating knit upper that adapts to the foot without feeling restrictive.

Cons

• Fit can be inconsistent: some users find the shoe narrow while others find it perfect for wider feet, so trying on or checking return options is recommended.
• As a highly cushioned neutral shoe, it is not ideal for runners who need significant stability or motion control.

Specifications

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for neutral runners and walkers who want maximum, plush cushioning and smooth transitions, backed by diabetic-friendly certification. It represents good value for anyone prioritizing comfort and long-wear support, though those needing firmer stability or a guaranteed wide fit should consider alternate models or trying a fitting first.

Frequently Asked Questions

Are these shoes good for walking?
Yes, customers report excellent comfort and cushioning for walking and everyday use, with notable heel padding.

Do they run true to size?
Fit reports are mixed; some users find them true to size while others note a narrower fit, so try them on if possible.

Are these shoes suitable for people with diabetic foot concerns?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating suitability for diabetic foot care.