Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style HSMS)

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: these shoes are for runners and walkers who want maximum plush cushioning with stable, smooth transitions. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, making daily miles feel cushioned without feeling sluggish. It is a solid choice for neutral runners, people with wide feet, and anyone seeking a comfortable shoe cleared for diabetic use and approved by a podiatry association.

Key Features

• DNA Tuned Cushion: The midsole uses dual-size cells to deliver soft heel landings and responsive forefoot toe-offs for a balanced ride.
• Neutral Support: Provides a neutral platform with the maximum amount of cushioning, suitable for road running, gym sessions, or long walks.
• Accommodating Fit: The double jacquard knit upper offers flexible, breathable coverage that adapts well to wider feet and longer outings.
• Smooth, Stable Transitions: A broad platform plus a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe motion.
• Medical Approvals: Certified PDAC A5500 diabetic footwear and granted the APMA Seal of Acceptance, signaling podiatric-friendly design choices.

Who It's For

The Glycerin 22 is best for neutral road runners and walkers who prioritize cushioning and comfort over maximal responsiveness. It works well for daily training runs, long walks up to several miles, and cross-training where plush support helps reduce fatigue. Runners with flat feet who need generous cushioning but not aggressive stability may also appreciate the fit.

Those who need firm corrective support or a motion-control platform should look at stability-specific models instead, and very lightweight race-day runners seeking minimal feel will find this shoe heavier and more cushioned than ideal.

Pros & Cons

Pros

• Excellent heel and overall cushioning that keeps walking and running comfortable for extended periods.
• Accommodating knit upper that breathes well and fits wider feet comfortably.
• Stable, smooth transitions thanks to a broad platform and tuned midsole geometry.
• Medical-friendly design with PDAC A5500 certification and APMA Seal of Acceptance.

Cons

• Generous cushioning may feel too soft for runners who prefer a firmer, more responsive ride.
• Not the best choice for those requiring strong corrective support or a stability-specific shoe.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Intended use	Road running, walking, cross training
Medical approval	PDAC A5500 certified; APMA Seal of Acceptance

Our Verdict

The Brooks Glycerin 22 is a top pick for runners and walkers who value plush cushioning and a comfortable, accommodating fit. Its DNA Tuned midsole and broad platform create smooth transitions and reliable support for everyday miles, making it good value for anyone seeking a soft, stable neutral trainer.

Frequently Asked Questions

Are these shoes good for wide feet?
The double jacquard knit upper is flexible and accommodating, and many customers report a comfortable fit for wider feet.

Is the Glycerin 22 suitable for diabetic use?
Yes, this model is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating podiatric-friendly features.

Should I buy this for speed workouts?
If you prioritize light weight and maximum responsiveness for speed sessions, a lighter, less-cushioned model would be a better choice than the plush Glycerin 22.