Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style NQKN)

In this review of the Brooks Mens Glycerin 22 neutral running shoe, the bottom line is simple: this is a plush, highly cushioned trainer best suited to runners and walkers who prioritize comfort and smooth transitions. The Glycerin 22 uses Brooks DNA Tuned midsole cells to deliver a soft landing in the heel and a more responsive toe-off, and it carries both APMA acceptance and PDAC A5500 diabetic shoe certification, which underlines its accommodating fit and protective cushioning. For anyone seeking maximum cushioning for road runs, long walks, or daily gym use, this shoe is worth close consideration.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells encourage a responsive toe-off for smoother gait transitions.
• Neutral Support: The shoe offers neutral support with the maximum amount of cushioning, making it suitable for road running and cross training without added motion control.
• Accommodating Fit: A newly engineered double jacquard knit upper delivers flexibility and breathability while fitting a range of foot shapes, including wider feet.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement for comfortable long-distance use.
• Medical Acceptance: Certified PDAC A5500 and granted the APMA Seal of Acceptance, indicating suitability for users who need extra cushioning and foot protection.

Who It's For

The Glycerin 22 is best for neutral runners, walkers, and gym-goers who want the maximum cushioning available in a road-running silhouette. It suits people with wider feet and those who value heel cushioning and a smooth ride over a highly responsive, race-oriented feel.

Runners who need strong stability or corrective motion control should look at support-specific models instead, such as the Glycerin GTS line. Minimalist runners or those seeking a lightweight racing shoe will likely find the Glycerin 22 too plush and not sufficiently responsive for tempo work.

Pros & Cons

Pros

• Excellent cushioning around the heel delivers comfortable landings on long walks and runs.
• Accommodating double jacquard knit upper fits a variety of foot shapes and breathes well.
• Broad platform and DNA Tuned design provide smooth, stable transitions through the stride.
• APMA Seal and PDAC A5500 certification add reassurance for users needing therapeutic cushioning.

Cons

• The maximal cushioning makes the shoe feel heavier and less responsive for speed sessions.
• Some buyers may consider the price-value balance mixed depending on how they use the shoe.

Specifications

Our Verdict

The Brooks Glycerin 22 is a top choice for runners and walkers who prioritize plush cushioning, comfort for wide feet, and smooth transitional mechanics. Its DNA Tuned midsole and broad platform make it a dependable daily trainer for road miles and long walks, and the APMA and PDAC credentials add practical value for users who need protective, therapeutic footwear.

Frequently Asked Questions

Is the Glycerin 22 good for wide feet?
Yes, the double jacquard knit upper is designed to be accommodating and many customers report a comfortable fit for wider feet.

Can I use the Glycerin 22 for speedwork?
It is primarily built for maximum cushioning and smooth rides, so runners seeking lightweight responsiveness for tempo or race sessions may prefer a less cushioned model.

Does this shoe provide medical or diabetic-friendly features?
Yes, it is certified PDAC A5500 and carries the APMA Seal of Acceptance, indicating suitability for users who need extra cushioning and protective support.