Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style VFB1)

Our review of the Brooks Mens Glycerin 22 finds it best for runners and walkers who prioritize maximum cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole that blends larger heel cells and smaller forefoot cells to deliver soft landings and lively toe-offs, making long runs and daily walking more comfortable without feeling sluggish. Fit varies among buyers, but the built quality, diabetic-friendly certification, and APMA Seal make it a compelling choice for anyone seeking plush, stable cushioning.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel create plush landings while smaller forefoot cells support responsive toe-offs for a balanced ride.
• Neutral Support: Designed as a neutral shoe that provides the maximum cushioning for road running, gym sessions, or casual walking without added stability posts.
• Accommodating Fit: The double jacquard knit upper stretches where needed and breathes well, giving a snug but flexible feel across most foot shapes.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot encourage stable and fluid heel-to-toe movement.
• Medical Approvals: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, offering reassurance for foot health concerns.

Who It's For

The Glycerin 22 is ideal for neutral runners who value cushioning over aggressive responsiveness, walkers who want a plush daily trainer, and anyone seeking footwear with medical approvals such as PDAC A5500 and APMA acceptance. It works well for road running, cross training, and general gym use where comfort and stability matter more than motion control.

Runners who need strong corrective support should look at the Glycerin GTS 22 or stability models instead, and those seeking an ultra-light racer will find the Glycerin 22 heavier and softer than performance racing shoes. Also test fit if you have very narrow or very wide feet, as customer reports vary on exact fit and true-to-size feel.

Pros & Cons

Pros

• Exceptional plush cushioning that reduces impact on long runs and walks.
• Comfortable heel padding and overall build quality praised by multiple owners.
• Stable, broad platform and tuned transitions that improve walking and running gait.
• Certified PDAC A5500 and APMA Seal provide added foot-health credibility.

Cons

• Fit is inconsistent across users; some report narrowness while others find it accommodating for wider feet.
• Not aimed at runners needing pronounced stability or a lightweight racing shoe.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Glycerin 22 is a strong choice for anyone who wants maximum, medically minded cushioning and smooth heel-to-toe transitions. Its DNA Tuned midsole and comfortable upper make it good value for runners and walkers seeking plush support, though shoppers with specific stability needs or unpredictable fit should try them on first.

Frequently Asked Questions

Are these shoes good for long-distance running?
Yes; the plush DNA Tuned cushioning and stable platform make them comfortable for longer road runs where cushioning is a priority.

Do they work for people with foot health concerns?
They are certified PDAC A5500 and carry the APMA Seal, indicating suitability for many diabetic or foot-sensitive users, but consult a clinician for individual needs.

Should I size up or down?
Fit reports vary, so try them on if possible; some users find them true to size while others recommend checking width for best comfort.