Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style Y1DR)
Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style Y1DR)
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Our review finds the Brooks Mens Glycerin 22 neutral running shoe is best for runners and walkers who prioritize plush cushioning and smooth transitions. In this review the standout is the updated DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft landings and responsive toe-offs, making it ideal for road runs, gym sessions, and long walks where comfort matters most.
Key Features
- Neutral support: Delivers a maximum amount of cushioning without added motion control so it works well for neutral runners and everyday wear.
- DNA Tuned cushion: Larger cells in the heel provide plush landings while smaller forefoot cells encourage energetic toe-offs for smoother cadence.
- Accommodating fit: The double jacquard knit upper stretches where needed and breathes well to reduce pressure on wider feet.
- Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot and eases heel-to-toe movement.
- Medical acceptance: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance for foot health considerations.
Who It's For
The Glycerin 22 is aimed at neutral runners, walkers, and those with wider or sensitive feet who want maximum cushioning during road runs or long walks. Its plush heel and responsive forefoot make it comfortable for multi-mile walks and daily gym use.
It is not aimed at runners who need strong corrective support; people with significant overpronation should consider a guided-support version such as the Glycerin GTS 22 or a stability shoe with firmer medial support.
Pros & Cons
Pros
- Excellent heel cushioning and soft landings thanks to the DNA Tuned midsole.
- Breathable, flexible double jacquard knit upper that accommodates wider feet.
- Stable, broad platform that smooths heel-to-toe transitions for walking and running.
Cons
- Provides neutral support only, so runners needing strong stability should look elsewhere.
Specifications
| Model | Glycerin 22 |
| Support type | Neutral |
| Midsole technology | DNA Tuned dual-size cells |
| Upper | Double jacquard knit |
| Medical seals | PDAC A5500 diabetic certified; APMA Seal of Acceptance |
| Predecessor | Glycerin 21 |
Our Verdict
The Brooks Glycerin 22 is a strong choice for runners and walkers who want maximum plush cushioning and a smooth ride without added stability features. Its accommodating knit fit and medical certifications add confidence for wider or sensitive feet, making it good value for anyone prioritizing comfort on roads and during long walks.
Frequently Asked Questions
Are these shoes good for wide feet?
Yes, the double jacquard knit upper offers an accommodating, flexible fit that works well for wider feet.
Is the Glycerin 22 a stability shoe?
No, the Glycerin 22 is a neutral support shoe; choose the Glycerin GTS 22 for added support.
Can I use these for walking long distances?
Yes, customers report strong comfort and cushioning for multi-mile walks and daily use.
Editor's Take
The Brooks Glycerin 22 is an excellent neutral running shoe for runners and walkers who want maximum plush cushioning, smooth transitions, and an accommodating knit fit; it is especially good for wider or sensitive feet.

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