Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style Y6LJ)

In this review of the Brooks Mens Glycerin 22 neutral running shoe, the bottom line is simple: if you want maximum plush cushioning and smooth heel-to-toe transitions for road runs, long walks, or daily training, this is a shoe to consider. The standout is the updated midsole: Brooks' DNA Tuned technology blends larger and smaller cells to deliver soft landings at the heel and energetic toe-offs in the forefoot. The Glycerin 22 also carries diabetic-friendly and APMA endorsements, which reinforces its comfort and protective fit for sensitive feet.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide a soft, plush landing while smaller forefoot cells return energy for a responsive toe-off.
• Neutral Support: Designed as a neutral shoe that offers the maximum amount of cushioning without added stability posts, suitable for natural foot strike.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce pressure points while remaining durable for everyday use.
• Smooth Transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and smooth the heel-to-toe roll.
• Medical Endorsements: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, supporting its suitability for sensitive or orthotic users.

Who It's For

The Glycerin 22 is best for runners and walkers who prioritize plush cushioning and comfort over aggressive responsiveness. It fits well for road runners, gym users, and anyone who spends extended time on their feet and wants protective, well-padded landings.

Runners seeking pronounced stability correction should look elsewhere, such as the Glycerin GTS line, which adds support. Those who need a very narrow racing shoe or a minimal, ground-feel trainer may also prefer a lighter, lower-cushion model.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that reduces impact on long runs and walks.
• Breathable, flexible double jacquard knit upper that accommodates foot movement.
• Stable broad platform and tuned transitions that make heel-to-toe motion smooth.
• Recognized by PDAC and APMA, which supports use by people with sensitive feet.

Cons

• Fit consistency varies by user; some wearers find it narrow while others report it fits wide feet, so trying before committing is advisable.
• Maximum cushioning adds weight compared with lighter, performance-oriented trainers.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned cushioning with varied cell sizes
Upper	Double jacquard knit, breathable and accommodating
Stability	Broad platform with tuned heel and forefoot
Endorsements	PDAC A5500 certified diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and everyday users who want the plushest cushioning Brooks offers in a neutral platform, paired with breathable fit and smooth transitions. It is good value for those who trade a bit of lightness for long-run comfort and medical-grade endorsements that help users with sensitive feet.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Reviewers consistently praise the cushioning and heel padding, making them comfortable for long walks and daily wear.

Do they provide stability for overpronation?
No. The Glycerin 22 is a neutral shoe; those needing added support should consider the Glycerin GTS variant.

Do they run true to size?
Fit varies among users-some find the fit perfect for wider feet while others feel they run narrow, so try them on if possible.