Brooks Mens Glycerin 22 Neutral Running Shoe - Plush (Style YQ73)

Our review of the Brooks Mens Glycerin 22 finds a premium neutral running shoe aimed at runners and walkers who prioritize maximum cushioning and smooth transitions. The standout reason to buy is the updated DNA Tuned midsole, which blends larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs, making long miles and everyday wear noticeably more comfortable. It also carries the APMA Seal of Acceptance and a PDAC A5500 diabetic shoe designation, adding confidence for those needing foot-friendly footwear.

Key Features

• Neutral support: Delivers the maximum amount of cushioning without added stability elements, ideal for neutral pronators who want a plush ride.
• DNA Tuned cushion: Larger heel cells give soft, plush landings while smaller forefoot cells help provide a responsive toe-off for smoother gait cycles.
• Accommodating fit: The double jacquard knit upper stretches and breathes to reduce pressure points and improve comfort during long runs or all-day wear.
• Smooth transitions: A broad platform combined with a tuned heel and forefoot promotes stable, heel-to-toe movement on the road or treadmill.
• Certified foot health: Approved as a PDAC A5500 diabetic shoe and bearing the APMA Seal of Acceptance, useful for shoppers concerned with foot health and comfort.

Who It's For

The Glycerin 22 is best for neutral runners and regular walkers who want the softest cushioning Brooks offers and value a smooth ride over long distances. It suits road running, cross training, gym sessions, and everyday walking where plush comfort and supportive transitions matter.

Shoppers who need strong corrective support or motion-control features should consider models with added stability, such as the Glycerin GTS line; similarly, those who require a persistently roomy toe box should try shoes specifically marketed for wide widths, as fit feedback is mixed.

Pros & Cons

Pros

• Exceptional cushioning and heel padding make runs and walks feel comfortable for extended wear.
• DNA Tuned midsole balances plush landings with responsive toe-offs for smoother transitions.
• Breathable double jacquard knit upper provides a flexible, accommodating fit and durability.
• Certified as a PDAC A5500 diabetic shoe and has APMA Seal of Acceptance for foot health reassurance.

Cons

• Fit is inconsistent for some customers-some find the shoe narrow compared with previous models, so sizing trials may be needed.
• As a maximum-cushion neutral shoe, it may not provide enough medial support for overpronators seeking motion control.

Specifications

Model	Glycerin 22
Support type	Neutral
Midsole technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Recommended uses	Road running, cross training, gym, walking

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for neutral runners and everyday walkers who want maximum cushioning, smooth transitions, and foot-health certifications. It represents good value for those prioritizing comfort and long-run plushness, though buyers sensitive to fit should verify sizing or try a wide option if available.

Frequently Asked Questions

Are these shoes good for walking?
Yes. Customers report excellent comfort and cushioning for walking and everyday use, with notable heel padding for longer periods on foot.

Do they run true to size?
Fit reports are mixed; some users find true-to-size while others describe a narrower feel, so trying them on or checking return options is recommended.

Is this shoe suitable for diabetic feet?
Yes. The Glycerin 22 is listed as a PDAC A5500 diabetic shoe and carries the APMA Seal, indicating it meets criteria for foot health considerations.