Brooks Mens Glycerin 22 Neutral Running Shoe - Smooth, Cushioned

In this review the Brooks Mens Glycerin 22 (Ghost 17 successor) is framed as a daily trainer for runners and walkers who prioritize plush cushioning and smooth transitions. The main reason to buy is the upgraded nitrogen-infused DNA Loft v3 midsole, which adds an extra 1mm in the heel and 3mm in the forefoot for a noticeably softer, more consistent ride mile after mile. Reviewers consistently cite comfort, heel cushioning, and support for wider or flat feet as standouts that make these shoes a reliable every-day companion.

Key Features

• Enhanced midsole: Nitrogen-infused DNA Loft v3 provides lightweight, soft cushioning that helps reduce impact on longer runs and walks.
• Smooth transitions: Precise flex grooves in the midsole promote a natural toe-off, helping maintain momentum during road runs and tempo efforts.
• Breathable upper: Double jacquard air mesh offers structured comfort and airflow to keep feet cool during extended wear.
• Durable outsole: Rubber compound with recycled silica balances durability and responsive rebound for consistent traction on pavement.
• Medical endorsements: Certified PDAC A5500 diabetic shoe and APMA Seal of Acceptance, beneficial for those needing proven foot protection and support.
• Carbon neutral: The Ghost 17 is a certified carbon neutral product, reducing environmental impact for eco-minded buyers.

Who It's For

The Glycerin 22 is best for daily road runners, regular walkers, and gym-goers who want a plush, neutral shoe that handles long miles and frequent use. Its cushioning and heel support suit people with wider feet or mild flat-footedness, and customers praising comfort for 6-mile walks underline its suitability for steady, longer sessions.

Runners seeking a lightweight racing shoe or maximalist trainer should look elsewhere, since the focus here is dependable, everyday comfort rather than minimal weight or aggressive responsiveness. Trail runners will also want a shoe with a chunkier lug pattern designed for off-road grip.

Pros & Cons

Pros

• Excellent heel and forefoot cushioning from updated DNA Loft v3 for a soft ride.
• Double jacquard mesh upper provides breathable comfort and a secure fit for longer use.
• Certified diabetic and APMA-accepted, offering validated support for foot health needs.
• Durable rubber outsole with recycled silica balances traction and rebound on roads.

Cons

• Shoes lean toward plush comfort rather than speed; not ideal for racers seeking lightweight performance.
• Perceived value varies among buyers, with some finding the price less compelling despite the features.

Specifications

Model	Glycerin 22 (Ghost 17 successor)
Cushioning	Nitrogen-infused DNA Loft v3 (extra 1mm heel, 3mm forefoot)
Support	Neutral
Upper	Double jacquard air mesh with kick-back collar
Outsole	Rubber compound with recycled silica
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Environmental	Certified carbon neutral product

Our Verdict

The Glycerin 22 is a smart pick for runners and walkers who want a plush, reliable daily trainer with proven foot-health credentials. Its upgraded DNA Loft v3 cushioning, smooth flex-guided transitions, and breathable upper make it good value for those prioritizing comfort and support over race-day speed.

Frequently Asked Questions

Are these shoes suitable for wide feet?
Yes. Many customers report a comfortable fit for wider feet and good support around the heel, making them a solid option for broader foot shapes.

Can I use these for long walks and runs?
Absolutely. The enhanced cushioning and supportive construction work well for long walks and steady runs, with several users noting comfort on multi-mile outings.

Do these work for flat feet?
They provide neutral support with substantial cushioning and have been reported to offer good support for mild flat-footedness, though severe stability needs may require a stability model.