Brooks Mens Glycerin 22 Neutral Running Shoe - Smooth, Cushioned Ride

In this review the Brooks Mens Glycerin 22 Neutral Running Shoe is presented as a dependable daily trainer for runners and walkers seeking plush comfort and smooth transitions. The single biggest reason to buy is the upgraded DNA LOFT v3 cushioning that adds extra millimeters in the heel and forefoot for a softer, more consistent feel mile after mile; that premium cushioning is also paired with a breathable upper and a rubber outsole that balances durability and rebound. Overall it reads like an everyday shoe designed for long-wear comfort and reliable road performance.

Key Features

• Enhanced cushioning: The updated midsole includes an extra 1mm of DNA LOFT v3 in the heel and 3mm in the forefoot to deliver softer, more consistent impact protection on runs and walks.
• Neutral support: Designed as a neutral shoe, it provides lightweight, responsive softness without corrective structure, making it versatile for road running and cross training.
• Smooth transitions: Precision flex grooves in the midsole promote a natural toe-off and improved flow through the gait cycle for steady momentum.
• Comfortable upper: The double jacquard air mesh upper increases breathability and adapts to the foot for a comfortable, secure fit while the kick-back collar adds mild structure.
• Durable outsole: The rubber compound with recycled silica aims to balance durability and responsive rebound so the shoe performs on a variety of hard surfaces.
• Medical certifications: This model is a certified PDAC A5500 Diabetic shoe and carries the APMA Seal of Acceptance, indicating attention to foot health and comfort.

Who It's For

The Glycerin 22 suits runners and walkers who prioritize plush cushioning and long-wear comfort, including people with wider feet or flat arches who appreciated the previous Ghost 16 model. It works well for road miles, daily training, long neighborhood walks of several miles, gym use, and travel where a comfortable shoe is needed for many hours.

Runners seeking aggressive stability, minimal weight for race-day speed, or maximal ground feel should look elsewhere; this shoe is built for softness and comfort over protection against heavy pronation or ultra-light performance.

Pros & Cons

Pros

• Excellent soft cushioning in heel and forefoot thanks to nitrogen-infused DNA LOFT v3.
• Breathable double jacquard air mesh upper offers a secure, comfortable fit for extended wear.
• Smooth transitions aided by designed midsole flex grooves improve toe-off efficiency.
• Recognized foot-health credentials with PDAC A5500 and APMA Seal, suitable for diabetic-friendly wear.

Cons

• As a neutral, cushioned shoe it may feel too soft or heavy for runners wanting a race-focused, minimal shoe.
• Some shoppers report mixed opinions on value compared with alternatives, though comfort and quality are consistently praised.

Specifications

Model	Glycerin 22 (successor to Ghost 16)
Cushioning	Nitrogen-infused DNA LOFT v3 with extra 1mm heel / 3mm forefoot
Support Type	Neutral
Upper	Double jacquard air mesh with kick-back collar
Outsole	Rubber compound with recycled silica for durability and rebound
Certifications	PDAC A5500 Diabetic approved; APMA Seal of Acceptance; carbon neutral product

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for anyone who wants plush, reliable cushioning and breathable comfort for daily runs and long walks; its neutral platform and smooth midsole transitions make it a versatile everyday trainer. It represents good value for runners prioritizing comfort and foot-health features, though those needing firm, race-oriented performance may prefer a lighter, less cushioned option.

Frequently Asked Questions

Is this shoe suitable for wide feet?
Yes, customers report it fits well for wider feet and offers comfortable room in the toe box.

Can I use this for long walking sessions?
Yes, the extra DNA LOFT v3 cushioning and breathable upper make it comfortable for extended walks of several miles.

Does it offer stability for flat feet?
It is a neutral shoe that provides good support and cushioning appreciated by many with flat feet, but it is not a corrective stability shoe for severe overpronation.