Brooks Mens Glycerin 22 Neutral Running Shoe - Smooth Cushioning

In this review of the Brooks Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a comfortable, everyday neutral trainer best for runners and walkers who want plush cushioning and reliable support for road miles. The most compelling reason to buy is the upgraded nitrogen-infused DNA LOFT v3 foam, which adds extra softness in the heel and forefoot so long runs, commutes, or long walks feel consistently cushioned mile after mile.

Key Features

• Enhanced Cushioning: The midsole uses nitrogen-infused DNA LOFT v3 with an extra 1mm in the heel and 3mm in the forefoot to deliver softer, lightweight comfort for each stride.
• Neutral Support: Designed as a neutral running shoe, it offers balanced responsiveness for road running, walking, and cross training without directional corrective elements.
• Smooth Transitions: Newly designed midsole flex grooves promote a natural toe-off and smoother transitions so maintaining pace feels more effortless.
• Breathable Upper: A double jacquard air mesh upper provides comfort and airflow while the kick-back collar adds structure and a snug, secure feel.
• Durable Outsole: Rubber compound made with recycled silica offers durability, light weight, and responsive rebound for varied pavement surfaces.
• Medical Recognition: Certified PDAC A5500 for diabetic-friendly fit and granted the APMA Seal of Acceptance for foot health.

Who It's For

The Brooks Mens Glycerin 22 is best for road runners and regular walkers who prioritize plush cushioning and all-day comfort, including those with wider feet or mild flat-footed tendencies who need supportive, soft heel cushioning. Its neutral platform and responsive rebound make it suited to daily training runs, long walks up to several miles, gym sessions, and travel where comfort and breathability matter.

Those who should look elsewhere include runners seeking a highly cushioned stability shoe for heavy overpronation, or racers wanting a minimal, performance-focused racing flat; this shoe favors comfort and smooth ride over racing lightness or corrective motion control.

Pros & Cons

Pros

• Excellent heel and forefoot cushioning from updated DNA LOFT v3 that keeps long walks and runs comfortable.
• Breathable double jacquard mesh upper that adapts to foot movement and helps keep feet cool.
• Durable rubber outsole with recycled silica gives good rebound and reliable wear on pavement.
• Certified for diabetic use and carries the APMA Seal, adding peace of mind for foot health.

Cons

• As a plush, neutral trainer it is not ideal for runners needing aggressive stability or a minimalist race shoe.
• Some buyers report mixed opinions on value compared with previous models.

Specifications

Model	Glycerin 22 (successor to Ghost 16/17 lineage)
Cushioning	Nitrogen-infused DNA LOFT v3 (extra 1mm heel, 3mm forefoot)
Support Type	Neutral
Upper	Double jacquard air mesh with kick-back collar
Outsole	Rubber compound with recycled silica
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance, certified carbon neutral

Our Verdict

The Brooks Mens Glycerin 22 is a strong choice for runners and walkers who put comfort and a smooth ride first; its upgraded DNA LOFT v3 cushioning and breathable upper make daily miles feel easier and reduce fatigue. For those who need motion control or a race-day minimal shoe, other models are better, but for everyday training and long walks this is good value and reliably comfortable.

Frequently Asked Questions

Are these shoes good for long walks?
Yes. Reviewers commonly praise the cushioning and heel comfort, noting they handle multi-mile walks well.

Do they fit wide feet?
Many customers report the fit works well for wider feet and provides a comfortable, adaptive upper without pinching.

Is this shoe suitable for people with foot health concerns?
It has PDAC A5500 diabetic certification and the APMA Seal, indicating it meets standards for foot health and diabetic-friendly fit.