Brooks Mens Glycerin GTS 22 Neutral Running Shoe - Cushioned Support

In this review of the Brooks Mens Glycerin GTS 22 Neutral Running Shoe the bottom line is clear: this is a cushioned, supportive daily trainer for runners and walkers who want plush landings and controlled motion. The Glycerin GTS 22 pairs Brooks' latest DNA Tuned cushion with the GuideRails support system to smooth transitions and limit excess movement, and it is even certified as a PDAC A5500 diabetic shoe. Reviewers repeatedly mention comfort and pain relief as the primary reasons to choose these shoes.

Key Features

• GuideRails support: Keeps excess motion in check so runners with mild overpronation feel more stable during road runs and gym sessions.
• DNA Tuned cushion: Larger heel cells and smaller forefoot cells deliver soft landings and energetic toe-offs for smoother heel-to-toe transitions.
• Accommodating fit: The double jacquard knit upper flexes for breathability and adapts to varying foot shapes for comfortable all-day wear.
• Broad platform: A wider sole base stabilizes the foot and reduces the sense of wobble when moving quickly or changing direction.
• Certified diabetic option: PDAC A5500 certification means the shoe meets standards for therapeutic footwear when that is required.

Who It's For

The Glycerin GTS 22 is best for road runners, walkers, and gym-goers who value plush cushioning combined with mild stability. People who have arch concerns or experience foot pain will likely appreciate the support and cushioning that many customers praised for reducing discomfort.

Runners who require very narrow racing fits or those prioritizing maximum durability for heavy mileage may want to compare other models, since some users reported mixed fit impressions and concerns about long-term wear in high-use scenarios.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that eases foot pain and supports long periods on your feet.
• GuideRails system provides noticeable stability without feeling intrusive.
• Breathable knit upper offers a flexible, accommodating fit for daily training and casual wear.
• PDAC A5500 certification makes it suitable for those needing diabetic-friendly footwear.

Cons

• Fit is mixed across customers; some find the shoe too narrow compared with previous versions.
• Durability was mentioned as a concern by several users after extended use.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Cushion technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Use case	Road running, cross training, gym, everyday wear
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Mens Glycerin GTS 22 is a strong choice for runners and walkers who want plush cushioning plus mild stability at a reasonable value. It soothes foot pain, supports natural motion, and works well for a mix of road runs and daily activity; those needing a very wide toe box or the utmost long-term outsole durability should try one of Brooks' other models first.

Frequently Asked Questions

Are these shoes good for people with foot pain?
Yes. Many users report reduced foot pain thanks to the cushioned DNA Tuned midsole and GuideRails support.

Do they fit true to size?
Fit is mixed; some customers find them true to size while others feel they run a touch narrow, so try your normal size or try on in store if possible.

Can I use them for gym cross training?
Yes. The stable platform and cushioning make them suitable for road running, gym workouts, and general cross training.