Brooks Women's Adrenaline GTS 22 - Smooth, Stable Ride

In this review of the Brooks Women's Adrenaline GTS 22 the bottom line is clear: these shoes are for runners who want dependable stability without sacrificing cushioning. The shoe's biggest selling point is its GuideRails holistic support combined with a full DNA LOFT midsole, which delivers a noticeably smoother, softer ride than prior generations while still controlling excess motion. For road runners, gym-goers and anyone needing help with overpronation, this model balances support and plush cushioning in a package that feels engineered rather than bulky.

Key Features

• GuideRails Support: Keeps excess movement in check to relieve stress on the knees and provide stable alignment during runs.
• 100% DNA LOFT Cushioning: Updated midsole gives high, energizing cushioning and a softer, smoother transition from heel to toe.
• 3D Fit Print Upper: Engineered mesh with strategic 3D print adds structure and a secure fit without adding unnecessary bulk.
• Segmented Crash Pad: Works with the cushioning to smooth the landing and improve flow through the gait cycle.
• Removable Molded Foam Insole: Allows for custom orthotics or extra bedding while maintaining comfortable in-shoe feel.
• Certified Comfort and Care: PDAC A5500 diabetic certification and APMA Seal of Acceptance indicate attention to foot health and fit.

Who It's For

The Adrenaline GTS 22 is ideal for women who overpronate and want a stable, cushioned shoe for road running, cross training or everyday walking. It suits runners who appreciate a softer midsole but still need guidance from a stability system that focuses on knee alignment rather than forcing foot motion.

Runners who prefer a minimal, very low-profile shoe or who need an ultra-lightweight racing flat should look elsewhere; this model prioritizes cushioning and structured support over minimal weight and maximal ground feel.

Pros & Cons

Pros

• Consistent, comfortable support from the GuideRails system that protects the knees.
• Very plush cushioning thanks to the DNA LOFT midsole for a smooth ride on roads and treadmills.
• Secure fit from the 3D Fit Print upper that limits bulk while holding the foot in place.
• Diabetic-friendly build and APMA acceptance make it a considerate choice for foot health.

Cons

• The shoe leans toward a more cushioned, structured ride, so it may feel heavier or less responsive to runners seeking a very fast, minimal shoe.
• Durability reports are mixed among customers, so long-term wear may vary by runner and usage.

Specifications

Brand	Brooks
Model	Adrenaline GTS 22
Support Type	Overpronation / Stability
Cushioning	100% DNA LOFT midsole
Upper	Engineered mesh with 3D Fit Print
Drop	12 mm differential
Certifications	PDAC A5500 diabetic certified, APMA Seal of Acceptance

Our Verdict

The Adrenaline GTS 22 is a smart pick for runners who need trusted stability and want a plush, forgiving ride. Its GuideRails system and full DNA LOFT midsole deliver comfort and knee-friendly support, making it good value for everyday road miles and cross training when stability and cushioning matter most.

Frequently Asked Questions

Are these true to size?
Brooks recommends ordering half to one size larger than your dress shoe; many runners find them true to that guidance.

Can I use custom orthotics?
Yes, the shoe includes a removable molded foam insole that allows room for custom inserts.

Is this shoe good for long runs?
Yes, the high cushioning and GuideRails support make it suitable for longer road runs, though some runners may prefer a lighter option for race day.