Brooks Womens Glycerin 22 Neutral Running Shoe - Cushioned Road

In this review the Brooks Womens Glycerin 22 Neutral Running Shoe is presented as a plush, neutral road trainer built for runners and walkers who prioritize cushioning and smooth transitions. The standout reason to consider these shoes is the updated DNA Tuned cushion, which blends larger heel cells with smaller forefoot cells for soft landings and energetic toe-offs, making the Glycerin 22 feel both luxurious and responsive on pavement or at the gym.

Key Features

• Neutral support: Designed for neutral runners, the shoe provides the maximum amount of cushioning without added stability posts so it suits road running, cross training, and gym sessions.
• DNA Tuned cushion: Dual-size midsole cells give plush heel impact absorption and a snappier forefoot for smoother heel-to-toe transitions.
• Accommodating fit: The double jacquard knit upper stretches to fit a range of foot shapes while remaining breathable and durable for long walks or runs.
• Smooth transitions: A broad platform with a tuned heel and forefoot helps stabilize the foot and promotes steady gait mechanics through each stride.
• Medical endorsements: Certified as a PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, indicating foot-health focused design.

Who It's For

The Glycerin 22 is best for women who want maximum cushioning in a neutral road shoe, including runners logging easy miles, walkers covering long distances, and gym users who prefer a soft, supportive base. Its certified diabetic fit and roomy feel also make it a sensible choice for shoppers needing extra comfort and foot-health credentials.

Those who need significant motion control or severe overpronation should look at stability alternatives, such as the Glycerin GTS line, which adds support. Runners seeking a minimalist, highly responsive race shoe should also consider lighter, lower-cushion models.

Pros & Cons

Pros

• Exceptionally plush cushioning with a soft, squishy midsole that reduces impact on knees and hips.
• Comfortable, accommodating upper that breathes well and fits several foot shapes.
• Stable, broad platform that smooths heel-to-toe transitions for confident road miles.
• Recognized foot-health credentials with PDAC A5500 and APMA acceptance.

Cons

• Sizing opinions vary; some customers report the shoe runs smaller than expected, so careful size checking is advised.
• Maximum cushioning adds weight and soft feel that may not satisfy runners who prefer a fast, minimal ride.

Specifications

Model	Glycerin 22 (women)
Support type	Neutral
Midsole technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Recommended use	Road running, cross training, gym, walking
Health certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is an excellent choice for runners and walkers who prioritize plush cushioning and a comfortable, accommodating fit. Its DNA Tuned midsole and broad platform deliver smooth transitions and reliable shock absorption, making it a good value for anyone needing maximum daily comfort rather than a lightweight race shoe.

Frequently Asked Questions

Do these run true to size?
Customer reports are mixed and some find them smaller than expected, so try your normal running size and consider half a size up if you prefer room in the toe box.

Are these suitable for people with diabetes?
Yes, the shoe is certified PDAC A5500 as a diabetic shoe and has the APMA Seal of Acceptance, indicating a foot-health focused design.

Is this shoe stable enough for long road runs?
The broad platform and tuned heel provide stable, smooth transitions for long runs, but those needing corrective support should opt for a stability model instead.